{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:11:28Z","timestamp":1777558288147,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders ( n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers ( p&lt;0.002 vs. baseline), mainly in males ( p=0.01), in those under 65 y ( p=0.03), and in subjects with Gensini score above median ( p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.<\/jats:p>","DOI":"10.1177\/1479164112443374","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T23:32:09Z","timestamp":1335223929000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome"],"prefix":"10.1177","volume":"10","author":[{"given":"Maria C","family":"Izar","sequence":"first","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil"},{"name":"National Institute of Complex Fluids, Institute of Physics, University of S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique 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