{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:05:26Z","timestamp":1786651526553,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>This study analyses discordance rates between attainment of therapeutic goals for apolipoprotein B100 (apoB) and both low-density lipoprotein\u2013cholesterol (LDL-C) and non-high-density lipoprotein\u2013cholesterol (non-HDL-C) in a sample of 152 patients with type 2 diabetes and chronic kidney disease from Gran Canaria (Spain), using treatment targets recommended by the American Diabetes Association\/American College of Cardiology (ADA\/ACC), the European Society of Cardiology\/European Atherosclerosis Society (ESC\/EAS) and by a Spanish population-based study. Among subjects with LDL-C levels at therapeutic goal, apoB was above target in 16.3% (ADA\/ACC), 6.5% (ESC\/EAS) and 39.1% (population-based criteria), and among subjects with non-HDL-C levels at therapeutic goal, apoB was above target in 10.5% (ADA\/ACC), 1.2% (ESC\/EAS) and 29.6% (population-based criteria). These findings show that clinical management would be very differently altered depending on the criteria used to set treatment targets for apoB. Cut-off points derived from population data identify a greater number of subjects suitable for a more intensive lipid-lowering therapy.<\/jats:p>","DOI":"10.1177\/1479164113511834","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T21:48:46Z","timestamp":1384897726000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential implications of the choice among three alternative treatment targets for apolipoprotein B100 in the management of patients with type 2 diabetes and chronic kidney disease"],"prefix":"10.1177","volume":"11","author":[{"given":"Mauro","family":"Boronat","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"},{"name":"Department of Medical and Surgical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Garc\u00eda-Cant\u00f3n","sequence":"additional","affiliation":[{"name":"Service of Nephrology, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-R\u00edos","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Genetics and Immunology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionisio L","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Batista","sequence":"additional","affiliation":[{"name":"Service of Nephrology, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ria\u00f1o","sequence":"additional","affiliation":[{"name":"Service of Clinical Biochemistry, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"N\u00f3voa","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain"},{"name":"Department of Medical and Surgical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"bibr1-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07098-2"},{"key":"bibr2-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.3.326"},{"key":"bibr3-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1619"},{"key":"bibr4-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn347"},{"key":"bibr5-1479164113511834","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0128"},{"key":"bibr6-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"bibr7-1479164113511834","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9018"},{"key":"bibr8-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr158"},{"key":"bibr9-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e328353fed5"},{"key":"bibr10-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.118356"},{"key":"bibr11-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.07.005"},{"key":"bibr12-1479164113511834","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02998.x"},{"key":"bibr13-1479164113511834","unstructured":"National Kidney Foundation. 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