{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:16:04Z","timestamp":1791418564215,"version":"4.3.3"},"reference-count":220,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This review is aimed at highlighting the potential mitogenic\/tumour growth\u2013promoting or antimitogenic\/tumour growth\u2013inhibiting effects of the main antihyperglycaemic drug classes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We review and discuss the most current studies evaluating the association between antidiabetic medications used in clinical practice and malignancies as described so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Metformin seems to be the only antidiabetic drug to exert protective effects both on monotherapy and also when combined with other oral antidiabetic drugs or insulins in several site-specific cancers. In contrast, several other drug classes may increase cancer risk. Some reason for concern remains regarding sulphonylureas and also the incretin-based therapies regarding pancreas and thyroid cancers and the sodium glucose cotransporter-2 inhibitors as well as pioglitazone regarding bladder cancer. The majority of meta-analyses suggest that there is no evidence for a causal relationship between insulin glargine and elevated cancer risk, although the studies have been controversially discussed. For \u03b1-glucosidase inhibitors and glinides, neutral or only few data upon cancer risk exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the molecular mechanisms are not fully understood, a potential risk of mitogenicity and tumour growth promotion cannot be excluded in case of several antidiabetic drug classes. However, more large-scale, randomized, well-designed clinical studies with especially long follow-up time periods are needed to get reliable answers to these safety issues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164114549553","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T23:57:12Z","timestamp":1410998232000},"page":"371-389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Antihyperglycaemic therapies and cancer risk"],"prefix":"10.1177","volume":"11","author":[{"given":"Stefan Z","family":"Lutz","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Centre for Diabetes Research (DZD), T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Staiger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Centre for Diabetes Research (DZD), T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Centre for Diabetes Research (DZD), T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Division of Nutritional and Preventive Medicine, Department of Internal Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Centre for Diabetes Research (DZD), T\u00fcbingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"bibr1-1479164114549553","first-page":"1680","volume":"382","author":"The global dominance of diabetes","year":"2013","journal-title":"Lancet"},{"key":"bibr2-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"bibr3-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70211-5"},{"key":"bibr4-1479164114549553","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1464-5491.2010.03132.x","volume":"28","author":"Mussig K","year":"2011","journal-title":"Diabet Med"},{"key":"bibr5-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1081488"},{"key":"bibr6-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1371"},{"key":"bibr7-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"bibr8-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0002"},{"key":"bibr9-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh161"},{"key":"bibr10-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.824"},{"key":"bibr11-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008862"},{"key":"bibr12-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2010.06.004"},{"key":"bibr13-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4158\/EP10357.RA"},{"key":"bibr14-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602619"},{"key":"bibr15-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058079"},{"key":"bibr16-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.12.007"},{"key":"bibr17-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31828189b2"},{"key":"bibr18-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.414"},{"key":"bibr19-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31827b8430"},{"key":"bibr20-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2051-6"},{"key":"bibr21-1479164114549553","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i6.936"},{"key":"bibr22-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.02875.x"},{"key":"bibr23-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9865-0"},{"key":"bibr24-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362830"},{"key":"bibr25-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330903"},{"key":"bibr26-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/970865"},{"key":"bibr27-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2741\/3301"},{"key":"bibr28-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.12.2063"},{"key":"bibr29-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0381"},{"key":"bibr30-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0263"},{"key":"bibr31-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0763-9"},{"key":"bibr32-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1042\/bj3480607"},{"key":"bibr33-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2310"},{"key":"bibr34-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.6.7933"},{"key":"bibr35-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0038"},{"key":"bibr36-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2994"},{"key":"bibr37-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38415.708634.F7"},{"key":"bibr38-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1440-6"},{"key":"bibr39-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1313"},{"key":"bibr40-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2175"},{"key":"bibr41-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1380"},{"key":"bibr42-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-20"},{"key":"bibr43-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0857"},{"key":"bibr44-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1558"},{"key":"bibr45-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1750-8"},{"key":"bibr46-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1509"},{"key":"bibr47-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1287"},{"key":"bibr48-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0157"},{"key":"bibr49-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01480.x"},{"key":"bibr50-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr020"},{"key":"bibr51-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr534"},{"key":"bibr52-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.19.6410"},{"key":"bibr53-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1804-y"},{"key":"bibr54-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"bibr55-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60953-3"},{"key":"bibr56-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2653-7"},{"key":"bibr57-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0512"},{"key":"bibr58-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.013"},{"key":"bibr59-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02223.x"},{"key":"bibr60-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24982"},{"key":"bibr61-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1791"},{"key":"bibr62-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0817"},{"key":"bibr63-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.016"},{"key":"bibr64-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0834-y"},{"key":"bibr65-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.13.8814"},{"key":"bibr66-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1612-1"},{"key":"bibr67-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20637"},{"key":"bibr68-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.06.006"},{"key":"bibr69-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1825"},{"key":"bibr70-1479164114549553","first-page":"631","volume":"25","author":"Yoshizumi T","year":"2004","journal-title":"Int J Oncol"},{"key":"bibr71-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2755"},{"key":"bibr72-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0002"},{"key":"bibr73-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4277"},{"key":"bibr74-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.04.016"},{"key":"bibr75-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8806"},{"key":"bibr76-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23640"},{"key":"bibr77-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1999.tb00668.x"},{"key":"bibr78-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1715"},{"key":"bibr79-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209267"},{"key":"bibr80-1479164114549553","first-page":"2170","volume":"86","author":"Ohta K","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr81-1479164114549553","first-page":"6213","volume":"61","author":"Palakurthi SS","year":"2001","journal-title":"Cancer Res"},{"key":"bibr82-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.2777"},{"key":"bibr83-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-013-0504-8"},{"key":"bibr84-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2308"},{"key":"bibr85-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0302"},{"key":"bibr86-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/2036"},{"key":"bibr87-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1080\/01926230490261320"},{"key":"bibr88-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21018"},{"key":"bibr89-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/2042"},{"key":"bibr90-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp256"},{"key":"bibr91-1479164114549553","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.2.238"},{"key":"bibr92-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12306"},{"key":"bibr93-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.112102"},{"key":"bibr94-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1278-x"},{"key":"bibr95-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12144"},{"key":"bibr96-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.05.006"},{"key":"bibr97-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"bibr98-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs328"},{"key":"bibr99-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25509"},{"key":"bibr100-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.5"},{"key":"bibr101-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0429"},{"key":"bibr102-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12151"},{"key":"bibr103-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1352"},{"key":"bibr104-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024038127156"},{"key":"bibr105-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8631"},{"key":"bibr106-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8763"},{"key":"bibr107-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/68.1.226"},{"key":"bibr108-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-007-0218-1"},{"key":"bibr109-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1106"},{"key":"bibr110-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27526"},{"key":"bibr111-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-013-0056-3"},{"key":"bibr112-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.068"},{"key":"bibr113-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-17"},{"key":"bibr114-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25495"},{"key":"bibr115-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2536"},{"key":"bibr116-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.01.014"},{"key":"bibr117-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.7"},{"key":"bibr118-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0177"},{"key":"bibr119-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.736"},{"key":"bibr120-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.642"},{"key":"bibr121-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0462"},{"key":"bibr122-1479164114549553","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.1.199"},{"key":"bibr123-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079968"},{"key":"bibr124-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"bibr125-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.124"},{"key":"bibr126-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0306"},{"key":"bibr127-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1147"},{"key":"bibr128-1479164114549553","first-page":"1970","volume":"358","author":"Ahmad SR","year":"2008","journal-title":"N Engl J Med"},{"key":"bibr129-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.149179"},{"key":"bibr130-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290269"},{"key":"bibr131-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1515-4"},{"key":"bibr132-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1109"},{"key":"bibr133-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-2043"},{"key":"bibr134-1479164114549553","first-page":"987","volume":"56","author":"Tripathy NR","year":"2008","journal-title":"J Assoc Physicians India"},{"key":"bibr135-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4158\/EP09104.CRR"},{"key":"bibr136-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P714"},{"key":"bibr137-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.018"},{"key":"bibr138-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.2720"},{"key":"bibr139-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01231.x"},{"key":"bibr140-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1755"},{"key":"bibr141-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1499"},{"key":"bibr142-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0340-7"},{"key":"bibr143-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.01.009"},{"key":"bibr144-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.019"},{"key":"bibr145-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12230"},{"key":"bibr146-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0936"},{"key":"bibr147-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00182.2012"},{"key":"bibr148-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-011-9552-8"},{"key":"bibr149-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1864"},{"key":"bibr150-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1272"},{"key":"bibr151-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1159\/000330447"},{"key":"bibr152-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.9.8756532"},{"key":"bibr153-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.4.7925114"},{"key":"bibr154-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4943(88)90006-4"},{"key":"bibr155-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197308302890901"},{"key":"bibr156-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2318"},{"key":"bibr157-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.09.008"},{"key":"bibr158-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1201"},{"key":"bibr159-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1585-0"},{"key":"bibr160-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2713"},{"key":"bibr161-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2504"},{"key":"bibr162-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0482"},{"key":"bibr163-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03652.x"},{"key":"bibr164-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01376.x"},{"key":"bibr165-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1185\/03007990902820519"},{"key":"bibr166-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.01.010"},{"key":"bibr167-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0703"},{"key":"bibr168-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010930918055"},{"key":"bibr169-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2741\/2856"},{"key":"bibr170-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-008-9188-9"},{"key":"bibr171-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.169"},{"key":"bibr172-1479164114549553","first-page":"2753","volume":"62","author":"Kajiyama H","year":"2002","journal-title":"Cancer Res"},{"key":"bibr173-1479164114549553","first-page":"2278","volume":"63","author":"Kajiyama H","year":"2003","journal-title":"Cancer Res"},{"key":"bibr174-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1377.007"},{"key":"bibr175-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0058"},{"key":"bibr176-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-8-14"},{"key":"bibr177-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.602964"},{"key":"bibr178-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-013-0024-0"},{"key":"bibr179-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12176"},{"key":"bibr180-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2502"},{"key":"bibr181-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305889"},{"key":"bibr182-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2413"},{"key":"bibr183-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4158\/EP10383.CR"},{"key":"bibr184-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4137\/CCRep.S10856"},{"key":"bibr185-1479164114549553","doi-asserted-by":"publisher","DOI":"10.4158\/EP11264.CR"},{"key":"bibr186-1479164114549553","first-page":"81","volume":"14","author":"Kunjathaya P","year":"2013","journal-title":"JOP"},{"key":"bibr187-1479164114549553","first-page":"491","volume":"51","author":"Faillie JL","year":"2014","journal-title":"Acta Diabetol"},{"key":"bibr188-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0169-1"},{"key":"bibr189-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.42"},{"key":"bibr190-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0249"},{"key":"bibr191-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.5.3278"},{"key":"bibr192-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8142"},{"key":"bibr193-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<492::AID-CNCR30>3.0.CO;2-I"},{"key":"bibr194-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114868"},{"key":"bibr195-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050953"},{"key":"bibr196-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0240"},{"key":"bibr197-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1080\/13813450903008628"},{"key":"bibr198-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1558-6"},{"key":"bibr199-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.6.999"},{"key":"bibr200-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203858"},{"key":"bibr201-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1210553"},{"key":"bibr202-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1452-2"},{"key":"bibr203-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1530-5"},{"key":"bibr204-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051814"},{"key":"bibr205-1479164114549553","doi-asserted-by":"publisher","DOI":"10.5301\/JBM.2012.9349"},{"key":"bibr206-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0263"},{"key":"bibr207-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1418-4"},{"key":"bibr208-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1572-8"},{"key":"bibr209-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1453-1"},{"key":"bibr210-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0476"},{"key":"bibr211-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2012.08.011"},{"key":"bibr212-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1444-2"},{"key":"bibr213-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2312-4"},{"key":"bibr214-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00576.x"},{"key":"bibr215-1479164114549553","doi-asserted-by":"crossref","first-page":"120","DOI":"10.47102\/annals-acadmedsg.V42N3p120","volume":"42","author":"Lai SW","year":"2013","journal-title":"Ann Acad Med Singapore"},{"key":"bibr216-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2011.10.002"},{"key":"bibr217-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-012-0197-7"},{"key":"bibr218-1479164114549553","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.8276"},{"key":"bibr219-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2171-z"},{"key":"bibr220-1479164114549553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053096"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164114549553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164114549553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164114549553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:22:24Z","timestamp":1777400544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164114549553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,17]]},"references-count":220,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1177\/1479164114549553"],"URL":"https:\/\/doi.org\/10.1177\/1479164114549553","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,17]]}}}