{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:54:29Z","timestamp":1781517269100,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to determine the impact of diabetes and diastolic dysfunction on exercise capacity in asymptomatic, normotensive patients with type 2 diabetes without coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 43 type 2 diabetes patients (age: 50\u2009\u00b1\u20095\u2009years) and 20 healthy controls (age: 48\u2009\u00b1\u20094\u2009years) were enrolled. Diastolic function was investigated by conventional pulsed-wave (PW) Doppler and tissue Doppler imaging (TDI). Exercise capacity was evaluated with cardiopulmonary exercise testing (CPET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In patients with type 2 diabetes, increase in resting heart rate (HR-rest) ( p\u2009=\u20090.013), decrease in maximum heart rate during exercise (HR-max) ( p\u2009&lt;\u20090.001) and exercise time ( p\u2009&lt;\u20090.001) compared with controls were significant. Patients had significantly increased minute ventilation volume (VE)\/maximum carbon dioxide discharge (VCO\n                      <jats:sub>2<\/jats:sub>\n                      ) ratio ( p\u2009&lt;\u20090.001), decreased maximum oxygen consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      -max) ( p\u2009&lt;\u20090.001), oxygen consumption at anaerobic threshold (VO\n                      <jats:sub>2<\/jats:sub>\n                      -an) ( p\u2009&lt;\u20090.001) and maximum carbon dioxide discharge (VCO\n                      <jats:sub>2<\/jats:sub>\n                      ) ( p\u2009&lt;\u20090.001) compared to controls indicating significantly reduced exercise capacity. HbA1c was inversely correlated with VO\n                      <jats:sub>2<\/jats:sub>\n                      -max ( r\u2009=\u2009\u22120.456, p\u2009&lt;\u20090.01) independent of the absence or presence of mild diastolic dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Exercise capacity was found to be significantly decreased in normotensive patients with type 2 diabetes without coronary artery disease, and this decrease was independent of diastolic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164114565631","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T21:08:43Z","timestamp":1423602523000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of diabetes and diastolic dysfunction on exercise capacity in normotensive patients without coronary artery disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Ahmet","family":"G\u00fcrdal","sequence":"first","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Kasikcioglu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sertac","family":"Yakal","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Bugra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul 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