{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:54:05Z","timestamp":1790805245862,"version":"4.1.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>With the intensification of antidiabetic treatment, there is an increasing risk of hypoglycaemia. We aimed to determine incidence, characteristics and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective, observational, multicenter cohort study. The included 3810 patients with type 2 diabetes had their treatment intensified at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of hypoglycaemia was 11.4% per year with 4.2\u2009\u00b1\u20094.4 episodes per patient. Hypoglycaemia was more frequent in patients with high blood glucose variability. Predictors were heart failure (odds ratio: 1.66; 95% confidence interval: 1.20\u20132.29) and insulin use (odds ratio: 4.03; 95% confidence interval: 3.05\u20135.33), with dipeptidyl peptidase\u20134 inhibitors being associated with reduced risk (odds ratio: 0.69; 95% confidence interval: 0.53\u20130.89). Macrovascular events were more frequent among patients reporting severe episodes of hypoglycaemia (odds ratio: 3.39; 95% confidence interval: 1.32\u20138.73). Microvascular events were more frequent in patients with non-severe episodes (odds ratio: 1.92; 95% confidence interval: 1.49\u20132.49).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Case-by-case evaluation of patients as well as appropriate selection of antidiabetic pharmacotherapy and blood glucose treatment goals could maximize the benefits while reducing the risks of antidiabetic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164115610470","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T20:24:09Z","timestamp":1447446249000},"page":"2-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Incidence, characteristics and impact of hypoglycaemia in patients receiving intensified treatment for inadequately controlled type 2 diabetes mellitus"],"prefix":"10.1177","volume":"13","author":[{"given":"Diethelm","family":"Tsch\u00f6pe","sequence":"first","affiliation":[{"name":"Stiftung \u2018Der herzkranke Diabetiker\u2019 in der Deutschen Diabetes-Stiftung, Bad Oeynhausen, Germany"},{"name":"Herz- und Diabeteszentrum Nordrhein-Westfalen, Medizinische Fakult\u00e4t, Universit\u00e4tsklinik der Ruhr Universit\u00e4t Bochum, Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bramlage","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie und Pr\u00e4ventive Medizin, Mahlow, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm K","family":"Gitt","sequence":"additional","affiliation":[{"name":"Institut 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