{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:14:38Z","timestamp":1781626478997,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association between plasma Dipeptidyl peptidase-4 (DPP4) activities and diabetic nephropathy in type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research design and methods:<\/jats:title>\n                    <jats:p>\n                      A total of 1193 newly diagnosed type 2 diabetic subjects were studied. Plasma DPP4 activity, mannose 6-phosphate receptor, inflammatory markers and oxidative stress parameters were measured in all participants. Diabetic nephropathy was defined as the presence of albuminuria or an estimated glomerular filtration rate\u2009&lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Participants in the highest quartile of DPP4 activity had higher HbA1c, homeostatic model assessment of insulin resistance, nitrotyrosine, 8-iso-PGF2a, interleukin-6, high-sensitivity C-reactive protein, mannose 6-phosphate receptor, urinary albumin-to-creatinine ratio and lower estimated glomerular filtration rate compared with participants in the lowest quartile (all p\u2009&lt;\u20090.001). DPP4 activities were associated positively with HbA1c, homeostatic model assessment of insulin resistance, nitrotyrosine, 8-iso-PGF2a, interleukin-6, high-sensitivity C-reactive protein, mannose 6-phosphate receptor, urinary albumin-to-creatinine ratio and negatively with estimated glomerular filtration rate (all p\u2009&lt;\u20090.001). In the highest DPP4 quartile, diabetic nephropathy risk was significantly higher (odds ratio: 3.77; 95% confidence interval: 2.34\u20136.07) than in the lowest quartile after adjustment for potential confounders. This association remained strong (2.85; 1.74\u20134.68) after further controlling for HbA1c, homeostatic model assessment of insulin resistance, nitrotyrosine and high-sensitivity C-reactive protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study shows that increased DPP4 activities are strongly and independently associated with diabetic nephropathy in type 2 diabetes. The associations between DPP4 and diabetic nephropathy, although strong, do not imply causality. There are however plausible mechanisms which could explain such a link.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164115615356","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T22:43:51Z","timestamp":1454021031000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study"],"prefix":"10.1177","volume":"13","author":[{"given":"Tianpeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guilin, P.R. China"},{"name":"Center of Diabetic Systems Medicine, Guilin Medical University, Guilin, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Diabetic Centre of Control and Prevention, The People\u2019s Liberation Army 520 Hospital, Mianyang, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Qin","sequence":"additional","affiliation":[{"name":"Medical Examination Center, Affiliated Hospital of Guilin Medical University, Guilin, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Guilin Medical University, Guilin, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Diabetic Systems Medicine, Guilin Medical University, Guilin, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Diabetic Systems Medicine, Guilin Medical University, Guilin, P.R. 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