{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:08:24Z","timestamp":1777558104208,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Lowering glucose levels, while avoiding hypoglycaemia, can be challenging in insulin-treated patients with diabetes. We evaluated the role of ambulatory glucose profile in optimising glycaemic control in this population. Insulin-treated patients with type 1 and type 2 diabetes were recruited into a prospective, multicentre, 100-day study and randomised to control ( n\u2009=\u200928) or intervention ( n\u2009=\u200959) groups. The intervention group used ambulatory glucose profile, generated by continuous glucose monitoring, to assess daily glucose levels, whereas the controls relied on capillary glucose testing. Patients were reviewed at days 30 and 45 by the health care professional to adjust insulin therapy. Comparing first and last 2\u2009weeks of the study, ambulatory glucose profile\u2013monitored type 2 diabetes patients ( n\u2009=\u200928) showed increased time in euglycaemia (mean\u2009\u00b1\u2009standard deviation) by 1.4\u2009\u00b1\u20093.5\u2009h\/day ( p\u2009=\u20090.0427) associated with reduction in HbA\n                    <jats:sub>1c<\/jats:sub>\n                    from 77\u2009\u00b1\u200915 to 67\u2009\u00b1\u200913\u2009mmol\/mol ( p\u2009=\u20090.0002) without increased hypoglycaemia. Type 1 diabetes patients ( n\u2009=\u200925) showed reduction in hypoglycaemia from 1.4\u2009\u00b1\u20091.7 to 0.8\u2009\u00b1\u20090.8\u2009h\/day ( p\u2009=\u20090.0472) associated with a marginal HbA\n                    <jats:sub>1c<\/jats:sub>\n                    decrease from 75\u2009\u00b1\u200910 to 72\u2009\u00b1\u20098\u2009mmol\/mol ( p\u2009=\u20090.0508). Largely similar findings were observed comparing intervention and control groups at end of study. In conclusion, ambulatory glucose profile helps glycaemic management in insulin-treated diabetes patients by increasing time spent in euglycaemia and decreasing HbA\n                    <jats:sub>1c<\/jats:sub>\n                    in type 2 diabetes patients, while reducing hypoglycaemia in type 1 diabetes patients.\n                  <\/jats:p>","DOI":"10.1177\/1479164115624680","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T20:49:56Z","timestamp":1458593396000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients"],"prefix":"10.1177","volume":"13","author":[{"given":"Ramzi A","family":"Ajjan","sequence":"first","affiliation":[{"name":"St. James\u2019s University Hospital, Leeds Teaching Hospitals Trust and LIGHT Laboratories, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Abougila","sequence":"additional","affiliation":[{"name":"County Durham and Darlington NHS Foundation Trust, County Durham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanth","family":"Bellary","sequence":"additional","affiliation":[{"name":"Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Collier","sequence":"additional","affiliation":[{"name":"University Hospital Ayr, Ayr, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Franke","sequence":"additional","affiliation":[{"name":"Rotherham Hospital NHS Foundation Trust, Rotherham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward B","family":"Jude","sequence":"additional","affiliation":[{"name":"Tameside Hospital NHS Foundation Trust, Ashton-under-Lyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry","family":"Rayman","sequence":"additional","affiliation":[{"name":"Ipswich Hospital NHS Trust, Ipswich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Robinson","sequence":"additional","affiliation":[{"name":"Royal United Hospitals Bath NHS Foundation Trust, Bath, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldev M","family":"Singh","sequence":"additional","affiliation":[{"name":"Royal Wolverhampton NHS Trust, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"bibr1-1479164115624680","unstructured":"International Diabetes Federation. 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