{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:27Z","timestamp":1790352447896,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Cardiovascular disease is the most common cause of mortality in type 1 diabetes; patients with albuminuria are at greatest risk. We investigated myocardial function and premature myocardial impairment in type 1 diabetes patients with and without albuminuria compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included a cross-sectional survey of 1093 type 1 diabetes patients from Steno Diabetes Center and 200 healthy controls. Conventional and tissue Doppler echocardiographic measurements were analysed in multivariable models in normoalbuminuria ( n\u2009=\u2009760), microalbuminuria ( n\u2009=\u2009227) and macroalbuminuria ( n\u2009=\u2009106). Investigators were blinded to degree of albuminuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For the type 1 diabetes patients, mean age was 49.6\u2009years, 53% were men and mean diabetes duration was 25.5\u2009years. In multivariable models systolic velocity s\u2032 did not differ between type 1 diabetes patients with normoalbuminuria and controls (\u03b2-coefficient [95% confidence interval]: \u22120.17 [\u22120.41; 0.08], p\u2009=\u20090.19), but was impaired between controls and microalbuminuria (\u22120.53 [\u22120.84; \u22120.23], p\u2009=\u20090.001) and macroalbuminuria (\u22120.59 [\u22120.96; \u22120.22], p\u2009=\u20090.002). Diastolic measurements ( e\u2032, a\u2032, e\u2032\/ a\u2032, and E\/ e\u2032) were all significantly impaired in type 1 diabetes, for example, e\u2032\/ a\u2032: normoalbuminuria, microalbuminuria and macroalbuminuria versus controls: \u22120.38 [\u22120.52; \u22120.23], p\u2009&lt;\u20090.001; \u22120.49 [\u22120.67; \u22120.32], p\u2009&lt;\u20090.001; and \u22120.81 [\u22121.03; \u22120.59], p\u2009&lt;\u20090.001. In age-related analyses, myocardial impairment occurred prematurely in type 1 diabetes compared to controls (e.g. E\/ e\u2032\u2009=\u20098; 9.2\u2009years [normoalbuminuria], 17.3\u2009years [microalbuminuria] and 41.4\u2009years [macroalbuminuria] prematurely, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In type 1 diabetes patients with albuminuria, both systolic and diastolic functions are impaired, whereas in patients without albuminuria only diastolic function is affected. Myocardial impairment is detectable many years prematurely in type 1 diabetes, especially in patients with albuminuria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164116637310","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T21:30:07Z","timestamp":1461274207000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Early myocardial impairment in type 1 diabetes patients without known heart disease assessed with tissue Doppler echocardiography: The Thousand &amp; 1 study"],"prefix":"10.1177","volume":"13","author":[{"given":"Magnus Thorsten","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"},{"name":"Steno Diabetes Center, Gentofte, Denmark"},{"name":"Department of Internal Medicine, Holbaek Hospital, Holbaek, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sogaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"},{"name":"Faculty of Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Ullits","family":"Andersen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"},{"name":"Department of Cardiology, Hospital Hvidovre, University of Copenhagen, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Fritz","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Theilade","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Almdal","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"},{"name":"Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Skov","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark"},{"name":"Institute for Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 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