{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:05:18Z","timestamp":1777557918212,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The importance of white matter injury induced by diabetes in stroke severity and prognosis is largely unknown. We aimed to investigate the relationship between diabetes-related white matter injury beyond stroke lesions with acute neurological deficits and clinical outcome after stroke. In total, 36 stroke patients within 3\u20137\u2009days after onset were enrolled. Neurological deficits on admission were assessed by National Institute of Health Stroke Score, and poor outcome at 3\u2009months was defined as modified Rankin score &gt;2. White matter tracts were compared between patients with diabetic and non-diabetic stroke using fractional anisotropy from diffusion tensor imaging. Regional white matter abnormality with decreased fractional anisotropy was observed in diabetic patients ( n\u2009=\u200918) when compared to non-diabetic patients ( n\u2009=\u200918). Decreased fractional anisotropy in ipsilesional distal corticospinal tract was independently associated with higher National Institute of Health Stroke Score motor component score ( \u03b2\u2009=\u2009\u22120.444, p\u2009=\u20090.005), and decreased fractional anisotropy in contralesional superior longitudinal fasciculus I was independently related to poor outcome (odds ratio, 0.900; p\u2009=\u20090.033). Our findings suggested that only white matter injury induced by diabetes in specific tracts like corticospinal tract and superior longitudinal fasciculus beyond stroke lesions has clinically relevant, providing insight into the mechanism of stroke recovery under the diabetic condition.<\/jats:p>","DOI":"10.1177\/1479164116675491","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T20:30:30Z","timestamp":1479155430000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["White matter injury induced by diabetes in acute stroke is clinically relevant: A preliminary study"],"prefix":"10.1177","volume":"14","author":[{"given":"Xinfeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerfan","family":"Jiaerken","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Education Ministry of China, Departments of Biomedical Engineering & Instrument Science Engineering, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Health System, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"bibr1-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1535"},{"key":"bibr2-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000085827.54986.89"},{"key":"bibr3-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000148477.65273.0C"},{"key":"bibr4-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.036"},{"key":"bibr5-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24510"},{"key":"bibr6-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596486"},{"key":"bibr7-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0261"},{"key":"bibr8-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0688-y"},{"key":"bibr9-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2488-2"},{"key":"bibr10-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0493"},{"key":"bibr11-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0342"},{"key":"bibr12-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"bibr13-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"bibr14-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.6.1311"},{"key":"bibr15-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"bibr16-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.063"},{"key":"bibr17-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000013069.24300.1D"},{"key":"bibr18-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21417"},{"key":"bibr19-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0814"},{"key":"bibr20-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.03.007"},{"key":"bibr21-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70016-X"},{"key":"bibr22-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420206"},{"key":"bibr23-1479164116675491","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.04.06.dc05-1818"},{"key":"bibr24-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70005-4"},{"key":"bibr25-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.066"},{"key":"bibr26-1479164116675491","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2038"},{"key":"bibr27-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094354"},{"key":"bibr28-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh186"},{"key":"bibr29-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.10.069"},{"key":"bibr30-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902280110"},{"key":"bibr31-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.003689"},{"key":"bibr32-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2320-07.2007"},{"key":"bibr33-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199609536.001.0001"},{"key":"bibr34-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.025"},{"key":"bibr35-1479164116675491","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.527713"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164116675491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164116675491","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164116675491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:11Z","timestamp":1777400411000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164116675491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/1479164116675491"],"URL":"https:\/\/doi.org\/10.1177\/1479164116675491","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}