{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:05:23Z","timestamp":1777557923407,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine the effects of a 12-week cardiac rehabilitation programme of aerobic and resistance exercise training on arterial stiffness, peak calf vasodilatory reserve, and haemostatic markers in patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Observational cohort study examining effects of 12 weeks of exercise training in 23 subjects (13 men, 10 women; mean age of 56.1\u2009\u00b1\u200910.1\u2009years) with type 2 diabetes mellitus. Subjects performed exercise training for 12 weeks [aerobic training 5\u2009days\/week, 70%\u201375% peak cardiovascular fitness (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) and resistance training 2\u20133\u2009days\/week, 60% of one repetition maximum]. Vascular stiffness (pulse-wave velocity), augmentation index, peak calf vasodilatory reserve, and VO\n                      <jats:sub>2peak<\/jats:sub>\n                      were measured pre- and post-exercise training. Secondary outcomes included heart rate variability and haemostatic measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      VO\n                      <jats:sub>2peak<\/jats:sub>\n                      increased by 16% (20.1\u2009\u00b1\u20095.5 vs 23.2\u2009\u00b1\u20098.8\u2009mL\/kg\/min, p\u2009=\u20090.002) and abdominal circumference was reduced (101.9\u2009\u00b1\u200913.3 vs 97.9\u2009\u00b1\u200912.7\u2009cm, p\u2009&lt;\u20090.03). Vascular function was improved including central arterial stiffness (central pulse-wave velocity: 8.44\u2009\u00b1\u20091.75 vs 8.02\u2009\u00b1\u20091.60\u2009m\/s, p\u2009=\u20090.026) and the aortic augmentation index (21.7\u2009\u00b1\u200910.6% vs 18.3\u2009\u00b1\u200912.6%, p\u2009=\u20090.005); peak calf vasodilatory reserve increased from 30.3\u2009\u00b1\u200910.6\u2009mL\/100\u2009mL\/min to 38.0\u2009\u00b1\u200915.3\u2009mL\/100\u2009mL\/min ( p\u2009=\u20090.04). No changes were seen in heart rate variability, blood lipids, glycated haemoglobin and C-reactive protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A 12-week cardiac rehabilitation programme of aerobic and resistance training significantly reduces arterial stiffness and improves aerobic fitness in individuals with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164116679078","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T11:02:01Z","timestamp":1484996521000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of an adapted cardiac rehabilitation programme on arterial stiffness in patients with type 2 diabetes without cardiac disease diagnosis"],"prefix":"10.1177","volume":"14","author":[{"given":"Anka P","family":"Brozic","sequence":"first","affiliation":[{"name":"Langs Community Health Centre, Cambridge, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Program, Toronto Rehab Institute, University Health Network, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M","family":"Goodman","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention and Rehabilitation Program, Toronto Rehab Institute, University Health Network, Toronto, ON, Canada"},{"name":"Goldring Centre for High Performance Sport, Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Cardiology, Mount Sinai Hospital, Toronto, ON, 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