{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:00:38Z","timestamp":1777557638307,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In total, 12 genetic risk scores for blood pressure, blood lipids and glycaemic traits were constructed. The genetic risk scores were tested for association with carotid intima-media thickness and plaques in patients with type 2 diabetes ( n\u2009=\u2009401) and in non-diabetic individuals ( n\u2009=\u2009648) and for association with glucose levels in two population-based cohorts ( n\u2009=\u20091328 and n\u2009=\u20096161).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In patients with type 2 diabetes, the genetic risk scores for pulse pressure were positively associated with plaque formation ( \u03b2\u2009=\u20090.036\u2009\u00b1\u20090.01 standard deviation\/allele, p\u2009=\u20090.003). The genetic risk score for diastolic blood pressure was negatively associated with carotid intima-media thickness ( \u03b2\u2009=\u2009\u20130.037\u2009\u00b1\u20090.01 standard deviation\/allele, p\u2009=\u20090.005), although not significant after correction for multiple testing ( p\u2009&lt;\u20090.0042). In a meta-analysis of individuals with and without type 2 diabetes, the high-density lipoprotein genetic risk scores showed a trend towards an inverse association with carotid intima-media thickness and plaques, while the low-density lipoprotein genetic risk scores showed a trend towards a positive association with plaque formation but did reach the statistical threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Genetic loci for pulse pressure are associated with plaque formation among patients with type 2 diabetes, suggesting an underlying genetic contribution to arterial stiffening and atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164118810365","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T06:36:32Z","timestamp":1546842992000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-0830","authenticated-orcid":false,"given":"Line","family":"Engelbrechtsen","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Diabetes Academy, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent E","family":"Appel","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresia M","family":"Schnurr","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Lundby-Christensen","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine, Nordsjaellands Hospital, Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea","family":"Skaaby","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Drivsholm","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark"},{"name":"The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Witte","sequence":"additional","affiliation":[{"name":"Danish Diabetes Academy, Odense, Denmark"},{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit E","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen, Gentofte, Denmark"},{"name":"National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Grarup","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluf","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The CIMT Trial Group10","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"bibr1-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6396.867"},{"key":"bibr2-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"bibr3-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"bibr4-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.2.434"},{"key":"bibr5-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90224-8"},{"key":"bibr6-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"bibr7-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875"},{"key":"bibr8-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.12.1705"},{"key":"bibr9-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.511584"},{"key":"bibr10-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1158"},{"key":"bibr11-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S8540"},{"key":"bibr12-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009302"},{"key":"bibr13-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.1812"},{"key":"bibr14-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.2.333"},{"key":"bibr15-1479164118810365","first-page":"286","volume":"21","author":"De Kreutzenberg SV","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"bibr16-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.841"},{"key":"bibr17-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.554121"},{"key":"bibr18-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000048214.56981.6F"},{"key":"bibr19-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000015329.15481.E8"},{"key":"bibr20-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000019909.71547.AA"},{"key":"bibr21-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000142132.20442.d8"},{"key":"bibr22-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.5.833"},{"key":"bibr23-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.920"},{"key":"bibr24-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00959.x"},{"key":"bibr25-1479164118810365","doi-asserted-by":"crossref","first-page":"e008376","DOI":"10.1136\/bmjopen-2015-008376","volume":"6","author":"Lundby-Christensen L","year":"2016","journal-title":"BMJ Open"},{"key":"bibr26-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00213.x"},{"key":"bibr27-1479164118810365","first-page":"121","volume":"27","author":"Hollnagel H","year":"1980","journal-title":"Dan Med Bull"},{"key":"bibr28-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-40"},{"key":"bibr29-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.12.037"},{"key":"bibr30-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"bibr31-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2797"},{"key":"bibr32-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3715"},{"key":"bibr33-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2385"},{"key":"bibr34-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2274"},{"key":"bibr35-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw061"},{"key":"bibr36-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04657.x"},{"key":"bibr37-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.11.1851"},{"key":"bibr38-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1245"},{"key":"bibr39-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9349-8"},{"key":"bibr40-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.11.083"},{"key":"bibr41-1479164118810365","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1463"},{"key":"bibr42-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.12.023"},{"key":"bibr43-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065222.34933.FC"},{"key":"bibr44-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000111829.46090.92"},{"key":"bibr45-1479164118810365","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04221"},{"key":"bibr46-1479164118810365","doi-asserted-by":"publisher","DOI":"10.5551\/jat.14001"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164118810365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164118810365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164118810365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:19:10Z","timestamp":1777400350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164118810365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/1479164118810365"],"URL":"https:\/\/doi.org\/10.1177\/1479164118810365","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}