{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:07:34Z","timestamp":1777558054182,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T00:00:00Z","timestamp":1549152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","award":["1,000,000 DKK"],"award-info":[{"award-number":["1,000,000 DKK"]}],"id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"name":"S\u00f8ster, and Verner Lipperts Foundation","award":["50,000 DKK"],"award-info":[{"award-number":["50,000 DKK"]}]},{"name":"Karen Anthonius Mindelegat","award":["25,000 DKK"],"award-info":[{"award-number":["25,000 DKK"]}]},{"name":"Danish Diabetes Academy supported by the Novo Nordisk Foundation","award":["1,800,000 DKK"],"award-info":[{"award-number":["1,800,000 DKK"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We examined 44 patients and 59 controls [mean (standard deviation) age 64.4\u2009\u00b1\u20099.9 vs 61.8\u2009\u00b1\u20099.7, male 50% vs 47%, diabetes duration mean (standard deviation) 7.7\u2009\u00b1\u20091.5] with coronary computed tomography angiography. Coronary plaques were quantified as total, calcified, non-calcified and low-density non-calcified plaque volumes (mm\n                      <jats:sup>3<\/jats:sup>\n                      ). Regional fat distribution was assessed by dual-energy X-ray absorptiometry, body mass index (kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), waist circumference (cm) and epicardial fat volume (mm\n                      <jats:sup>3<\/jats:sup>\n                      ). Endothelial function and systemic inflammation were evaluated by peripheral arterial tonometry (log transformed Reactive Hyperemia Index) and C-reactive protein (mg\/L).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Body mass index and waist circumference ( p\u2009&lt;\u20090.02) were associated with coronary plaque volumes. Body mass index was associated with low-density non-calcified plaque volume after adjustment for age, sex and diabetes status ( p\u2009&lt;\u20090.01). Truncal fat mass ( p\u2009&gt;\u20090.51), waist circumference ( p\u2009&gt;\u20090.06) and epicardial adipose tissue ( p\u2009&gt;\u20090.17) were not associated with coronary plaque volumes in adjusted analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Body mass index is associated with coronary plaque volumes in diabetic as well as non-diabetic individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164119825761","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T01:49:51Z","timestamp":1549244991000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Volumes of coronary plaque disease in relation to body mass index, waist circumference, truncal fat mass and epicardial adipose tissue in patients with type 2 diabetes mellitus and controls"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-1278","authenticated-orcid":false,"given":"S\u00f8ren","family":"Gullaksen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-5550","authenticated-orcid":false,"given":"Kristian L\u00f8kke","family":"Funck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"Laugesen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels Krarup","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damini","family":"Dey","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per L\u00f8gstrup","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Steno Diabetes Center, Aarhus, 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