{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:07:37Z","timestamp":1777558057059,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This pooled analysis assessed the efficacy of ertugliflozin versus placebo as monotherapy or with other antihyperglycaemic agents across patient subgroups defined by demographic and disease characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from three phase III randomised, placebo-controlled, double-blind studies (NCT01958671, NCT02033889 and NCT02036515) with similar designs and populations were pooled ( N\u2009=\u20091544).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At Week 26, placebo-adjusted least squares mean changes from baseline in glycated haemoglobin with ertugliflozin 5 and 15\u2009mg were \u22120.8% (95% confidence interval: \u22120.9, \u22120.7) and \u22120.9% (\u20131.0, \u22120.8), respectively. Reductions were consistent across subgroups. Placebo-adjusted least squares mean changes in body weight were \u22121.8\u2009kg (\u22122.2, \u22121.4) for both ertugliflozin doses; for systolic blood pressure, these were \u22123.4\u2009mmHg (\u22124.8, \u22122.0) and \u22123.5\u2009mmHg (\u22124.9, \u22122.0) for ertugliflozin 5 and 15\u2009mg, respectively. Higher proportions of patients receiving ertugliflozin had glycated haemoglobin &lt;7.0%, weight loss \u2a7e5% and systolic blood pressure &lt;130\u2009mmHg versus placebo. Ertugliflozin and placebo safety profiles were similar, including incidences of hypoglycaemia, urinary tract infection and hypovolaemia. Genital mycotic infection and adverse events related to osmotic diuresis were more common with ertugliflozin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ertugliflozin demonstrated efficacy as monotherapy or with other antihyperglycaemic agents in patients with different demographic and disease characteristics and was generally well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164119842513","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:26:47Z","timestamp":1557728807000},"page":"415-423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of ertugliflozin in monotherapy or combination therapy in patients with type 2 diabetes: A pooled analysis of placebo-controlled studies"],"prefix":"10.1177","volume":"16","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Tarasenko","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven G","family":"Terra","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Andover, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Huyck","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Wu","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annpey","family":"Pong","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto A","family":"Calle","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Gallo","sequence":"additional","affiliation":[{"name":"Pfizer Pharma GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Darekar","sequence":"additional","affiliation":[{"name":"Pfizer R&D UK Ltd, Tadworth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Groton, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"bibr1-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.243"},{"key":"bibr2-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021887"},{"key":"bibr3-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"bibr4-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"bibr5-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"bibr6-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13299"},{"key":"bibr7-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029190"},{"key":"bibr8-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.009"},{"key":"bibr9-1479164119842513","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0033"},{"key":"bibr10-1479164119842513","unstructured":"Food Drug Administration. STEGLATRO\n                      TM\n                      (ertugliflozin). Prescribing Information, 2017, https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/209803s000lbl.pdf"},{"key":"bibr11-1479164119842513","unstructured":"European Medicines Agency. STEGLATRO\n                      TM\n                      summary of product characteristics, 2018, https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/steglatro-epar-product-information_en.pdf"},{"key":"bibr12-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12888"},{"key":"bibr13-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13103"},{"key":"bibr14-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13116"},{"key":"bibr15-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13194"},{"key":"bibr16-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0358-0"},{"key":"bibr17-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0354-4"},{"key":"bibr18-1479164119842513","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-s004"},{"key":"bibr19-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780040211"},{"key":"bibr20-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009417"},{"key":"bibr21-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12670"},{"key":"bibr22-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0511-0"},{"key":"bibr23-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2016.06.003"},{"key":"bibr24-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1177\/1479164115585298"},{"key":"bibr25-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1082991"},{"key":"bibr26-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1391759"},{"key":"bibr27-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1085-8"},{"key":"bibr28-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.12.016"},{"key":"bibr29-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.017"},{"key":"bibr30-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2015.11.005"},{"key":"bibr31-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0337-5"},{"key":"bibr32-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022194"},{"key":"bibr33-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800256"},{"key":"bibr34-1479164119842513","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00052-8"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164119842513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164119842513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164119842513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:46Z","timestamp":1777400446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164119842513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/1479164119842513"],"URL":"https:\/\/doi.org\/10.1177\/1479164119842513","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,13]]}}}