{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:07:41Z","timestamp":1777558061106,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Korean Centers for Disease Control and Prevention","award":["2007-E71001-00, 2008-E71001-00, 2015-P71001-00, an"],"award-info":[{"award-number":["2007-E71001-00, 2008-E71001-00, 2015-P71001-00, an"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Although reported to be independent of obesity, the longitudinal changes of left ventricular structure and function have not been well characterized in normal-weight individuals with type 2 diabetes compared with overweight\/obese individuals with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 558 participants in the Korean Genome and Epidemiology Study who underwent tissue Doppler echocardiography at baseline (cycle 4) and after 8\u2009years (cycle 8) were classified into three groups based on body mass index and diabetes status: (1) normal-weight individuals without type 2 diabetes, (2) normal-weight individuals with type 2 diabetes and (3) overweight\/obese individuals with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Only overweight\/obese individuals with type 2 diabetes group had higher adjusted left ventricular mass index and lower tissue Doppler imaging early diastolic velocity and E\/Em ratio compared with the normal-weight individuals without type 2 diabetes group at baseline and after 8\u2009years. Participants in overweight\/obese individuals with type 2 diabetes group also showed the higher prevalence and odds of left ventricular hypertrophy (16.0%; adjusted odds ratio: 2.24; 95% confidence interval: 1.22\u20135.06) and left ventricular diastolic dysfunction (49.1%; 3.45; 1.01\u20134.32). Among participants with normal left ventricular structure and function at baseline, only overweight\/obese individuals with type 2 diabetes group was associated with greater incidence of left ventricular hypertrophy (relative risk: 2.28; 1.04\u20134.98) over 8\u2009years but not diastolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cross-sectional and longitudinal observations suggest that increasing body mass index category and its associated metabolic abnormalities at baseline are associated with an increased risk for left ventricular hypertrophy and greater impairment in left ventricular diastolic parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164119843760","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:30:21Z","timestamp":1557729021000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal changes in left ventricular structure and function in patients with type 2 diabetes: Normal weight versus overweight\/obesity"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-2713","authenticated-orcid":false,"given":"Seong Hwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology, Korea University Ansan Hospital, Ansan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Chul","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangbuk Samsung Medical Center, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ku","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juri","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Gerontology and Metabolism, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Korea University Ansan Hospital, Ansan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun H","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Gerontology and Metabolism, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chol","family":"Shin","sequence":"additional","affiliation":[{"name":"Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, South Korea"},{"name":"Department of Pulmonology and Critical Care Medicine, Korea University Ansan Hospital, Ansan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"bibr1-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"bibr2-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht108"},{"key":"bibr3-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"bibr4-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.03.015"},{"key":"bibr5-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv509"},{"key":"bibr6-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.19.2271"},{"key":"bibr7-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.12.026"},{"key":"bibr8-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv316"},{"key":"bibr9-1479164119843760","volume-title":"The Asia-Pacific perspective: redefining obesity and its treatment","author":"World Health Organization, International Association for the Study of Obesity, International Obesity Task Force","year":"2000"},{"key":"bibr10-1479164119843760","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-Srev01"},{"key":"bibr11-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"bibr12-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1632-z"},{"key":"bibr13-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep164"},{"key":"bibr14-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2668"},{"key":"bibr15-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92814-V"},{"key":"bibr16-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02051-X"},{"key":"bibr17-1479164119843760","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1496"},{"key":"bibr18-1479164119843760","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1094"},{"key":"bibr19-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx511"},{"key":"bibr20-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.12.012"},{"key":"bibr21-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328364fb58"},{"key":"bibr22-1479164119843760","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.1.35"},{"key":"bibr23-1479164119843760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.09.013"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164119843760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164119843760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164119843760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:47Z","timestamp":1777400447000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164119843760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/1479164119843760"],"URL":"https:\/\/doi.org\/10.1177\/1479164119843760","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,13]]}}}