{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:16:28Z","timestamp":1791645388528,"version":"4.3.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"novo nordisk fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Besides being a metabolic disease, diabetes is considered a vascular disease as many of the complications relate to vascular pathologies. The aim of this study was to investigate how vascular tone and reactivity and vascular cell metabolism were affected in type 2 diabetes mellitus and whether \u03b2-hydroxybutyrate could have a positive effect as alternative energy substrate. Isolated mesenteric arteries of db\/db and control mice were incubated in media containing [U-\n                    <jats:sup>13<\/jats:sup>\n                    C]glucose or [U-\n                    <jats:sup>13<\/jats:sup>\n                    C]\u03b2-hydroxybutyrate, and tissue extracts were analysed by mass spectrometry. Functional characterization was performed by wire myography to assess vasodilation and vasocontraction. Hypermetabolism of glucose and \u03b2-hydroxybutyrate was observed for mesenteric arteries of db\/db mice; however, hypermetabolism was significant only with \u03b2-hydroxybutyrate as energy substrate. The functional characterization showed impaired endothelial-dependent vasodilation in mesenteric arteries of the db\/db mice, whereas the contractility was unaffected. This study provides evidence that the endothelial cells are impaired, whereas the vascular smooth muscle cells are more robust and seemed less affected in the db\/db mouse. Furthermore, the results indicate that hypermetabolism of energy substrates may be due to adaptive changes in the mesenteric arteries.\n                  <\/jats:p>","DOI":"10.1177\/1479164119865885","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T05:42:03Z","timestamp":1564551723000},"page":"539-548","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db\/db mice"],"prefix":"10.1177","volume":"16","author":[{"given":"Lene","family":"Arildsen","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Velde","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Soenderby","family":"Waagepetersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-6549","authenticated-orcid":false,"given":"Jakob Borre Dahl","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-0326","authenticated-orcid":false,"given":"Majid","family":"Sheykhzade","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"bibr1-1479164119865885","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2003.58.6.001"},{"key":"bibr2-1479164119865885","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306825"},{"key":"bibr3-1479164119865885","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.12.009"},{"key":"bibr4-1479164119865885","doi-asserted-by":"crossref","unstructured":"Economic costs of diabetes in the U.S. in 2017. 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