{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:06:03Z","timestamp":1780524363674,"version":"3.54.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011841","name":"xinxiang medical university","doi-asserted-by":"publisher","award":["XYBSKYZZ201812, XYBSKYZZ505319, XYBSKYZZ201626"],"award-info":[{"award-number":["XYBSKYZZ201812, XYBSKYZZ505319, XYBSKYZZ201626"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960015"],"award-info":[{"award-number":["81960015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800051"],"award-info":[{"award-number":["81800051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874312"],"award-info":[{"award-number":["81874312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804197"],"award-info":[{"award-number":["U1804197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main methods:<\/jats:title>\n                    <jats:p>Male Sprague\u2013Dawley rats were allocated into six groups. The control group received a conventional diet. The diabetic group received a high-sucrose high-fat (HSHF) diet for 4\u2009weeks and then was fasted and injected with streptozotocin (STZ); subsequently, the rats received a HSHF diet for another 4\u2009weeks to develop diabetes. The four treatment groups were diabetic rats that received intragastric metformin (500\u2009mg\/kg\/day) or EGCG (25, 50, and 100\u2009mg\/kg\/day) for 10\u2009weeks. All groups except the control group received a HSHF diet throughout the experiment. Several biochemical parameters such as fasting blood glucose (FBG), postprandial blood glucose (PBG), liver glycogen, muscle glycogen, fasting serum insulin (FSI), homeostasis model of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFA), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess the effects of EGCG on glycemic control, insulin resistance, lipid profile, and oxidative stress. Furthermore, oxidative stress in pancreatic islet \u03b2 cells was detected by dihydroethidium staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings:<\/jats:title>\n                    <jats:p>A HSHF diet and STZ injection induced T2DM, as indicated by changed blood glucose and body weight, which was accompanied by insulin resistance, an altered lipid profile, and oxidative stress. Interestingly, EGCG treatment dose-dependently recovered these indexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>EGCG successfully ameliorated glycemic control and insulin sensitivity while reducing the lipid profile and oxidative stress in a T2DM rat model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164120966998","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T11:51:23Z","timestamp":1607601083000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats"],"prefix":"10.1177","volume":"17","author":[{"given":"Wenru","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China"},{"name":"Department of pharmacy, The first Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianheng","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China"},{"name":"Henan international joint laboratory of cardiovascular remodeling and drug intervention, Xinxiang, Henan, China"},{"name":"Xinxiang key laboratory of vascular remodeling intervention and molecular targeted therapy drug development, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second 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