{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:29:12Z","timestamp":1791930552941,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in the development of atherosclerosis and several studies have suggested that inhibiting NLRP3 inflammasome could be a potential therapeutic approach to treat atherosclerosis. Baicalin is a flavone glycoside with anti-inflammation, anti-oxidative activities. The inhibition of NLRP3 inflammasome activation by baicalin has also been described. Therefore, the effects of baicalin on NLRP3 inflammasome activation and atherosclerosis were evaluated in present study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We established the apolipoprotein E-deficient atherosclerosis mice model. After baicalin treatment, the IL-1, IL-18, and reactive oxygen species (ROS) production, and the plaque area was monitored. We also measured the NLRP3, ASC, caspase-1, ICAM-1, and VCAM-1 expression in atherosclerosis mice after baicalin treatment. We silenced NLRP3 by administration of lentivirus expressing NLRP3 shRNA to atherosclerosis mice and monitored the IL-1, IL-18, and ROS production, and NLRP3 inflammasome activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baicalin remarkably inhibited the production of IL-1, IL-18, mitochondria ROS, total ROS, ICAM-1, and VCAM-1. Baicalin reduced the expression of NLRP3 inflammasome and suppressed its activation. Baicalin significantly reduced the plaque area. Silencing NLRP3 resulted in decreased production of IL-1, IL-18, mitochondria ROS, total ROS, ICAM-1, and VCAM-1, and inhibition of NLRP3 inflammasome activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Baicalin ameliorated atherosclerosis by inhibiting NLRP3 inflammasome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164120977441","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T05:16:34Z","timestamp":1606972594000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":61,"title":["Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice"],"prefix":"10.1177","volume":"17","author":[{"given":"Jingfei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Surgery, Third People\u2019s Hospital of Liaocheng City, Liaocheng, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Third People\u2019s Hospital of Liaocheng City, Liaocheng, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Third People\u2019s Hospital of Liaocheng City, Liaocheng, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopedic, Third People\u2019s Hospital of Liaocheng City, Liaocheng, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-4176","authenticated-orcid":false,"given":"Qingbo","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"bibr1-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"bibr2-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"bibr3-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"bibr4-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.1000"},{"key":"bibr5-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2013.01.012"},{"key":"bibr6-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9286458"},{"key":"bibr7-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/507208"},{"key":"bibr8-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0013-0"},{"key":"bibr9-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.01.026"},{"key":"bibr10-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.107"},{"key":"bibr11-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-014-2192-2"},{"key":"bibr12-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt534"},{"key":"bibr13-1479164120977441","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01409"},{"key":"bibr14-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.10.010"},{"key":"bibr15-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916631032"},{"key":"bibr16-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000128849.12617.f4"},{"key":"bibr17-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.024"},{"key":"bibr18-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13086"},{"key":"bibr19-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43713"},{"key":"bibr20-1479164120977441","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s003920050241","volume":"87","author":"Mugge A.","year":"1998","journal-title":"Z Kardiol"},{"key":"bibr21-1479164120977441","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17001"},{"key":"bibr22-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"bibr23-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711710311"},{"key":"bibr24-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100100"},{"key":"bibr25-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"bibr26-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000064374.15232.C3"},{"key":"bibr27-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.10.012"},{"key":"bibr28-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19293-2"},{"key":"bibr29-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05503-B"},{"key":"bibr30-1479164120977441","doi-asserted-by":"publisher","DOI":"10.2217\/imt.14.106"},{"key":"bibr31-1479164120977441","first-page":"5","author":"Paramel Varghese G","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"bibr32-1479164120977441","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02142"},{"key":"bibr33-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19293-2"},{"key":"bibr34-1479164120977441","first-page":"605","volume":"30","author":"Chang WS","year":"2016","journal-title":"In Vivo"},{"key":"bibr35-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711413799"},{"key":"bibr36-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.04.020"},{"key":"bibr37-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.460"},{"key":"bibr38-1479164120977441","first-page":"846","volume":"13","author":"Wang B","year":"2016","journal-title":"Journal of Geriatric Cardiology: JGC"},{"key":"bibr39-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.02.037"},{"key":"bibr40-1479164120977441","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.06.039"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164120977441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1479164120977441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164120977441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:19:37Z","timestamp":1777400377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164120977441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/1479164120977441"],"URL":"https:\/\/doi.org\/10.1177\/1479164120977441","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"article-number":"1479164120977441"}}