{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:13:43Z","timestamp":1787019223239,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tissue inhibitor of metalloproteinase-1 (TIMP-1) has been suggested as a marker for abnormal regulation of tissue remodelling in type 1 diabetes. Metalloproteinase-9 (MMP-9) has been associated with matrix turnover, and Neutrophil gelatinase associated lipocalin (NGAL) is a marker of tubular injury in diabetic nephropathy. The aim was to analyse these biomarkers to unmask early diabetic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-three type 1 diabetes patients, aged 20\u201335\u2009years, and disease duration 20\u2009\u00b1\u20095.3\u2009years were included. Along with clinical examination, neurophysiological measurements, routine biochemistry, plasma concentrations of TIMP-1, MMP-9 and NGAL were determined with immunoenzymatic techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>TIMP-1 correlated with abnormal unilateral and bilateral vibratory sense foot perception ( r\u2009=\u2009\u22120.49 and r\u2009=\u2009\u22120.51, respectively), foot neuropathy impairment assessment score (NIA; r\u2009=\u2009\u22120.55), neuropathy symptom assessment score ( r\u2009=\u20090.42), microalbuminuria ( r\u2009=\u20090.50) and eGFR ( r\u2009=\u2009\u22120.45). MMP-9 correlated with impaired foot NIA ( r\u2009=\u20090.51). Multiple regression analysis showed an association for TIMP-1 ( p\u2009=\u20090.004) with impaired neurophysiological examinations and renal dysfunction along with NGAL ( p\u2009=\u20090.016 and p\u2009=\u20090.015 respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study suggests that plasma levels of TIMP-1, MMP-9 and NGAL may serve as useful biomarkers in unravelling subclinical neuropathy and nephropathy in type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641211002470","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T07:18:17Z","timestamp":1616829497000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy"],"prefix":"10.1177","volume":"18","author":[{"given":"Nektaria","family":"Papadopoulou-Marketou","sequence":"first","affiliation":[{"name":"Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences (HMV), Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, Medical School, Aghia Sophia Children\u2019s Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-0427","authenticated-orcid":false,"given":"Per A","family":"Whiss","sequence":"additional","affiliation":[{"name":"Division of Drug Research, Department of Biomedical and Clinical Sciences (BKV), Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas C","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Division of Drug Research, Department of Biomedical and Clinical Sciences (BKV), Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hyllienmark","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papassotiriou","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aghia Sophia Children\u2019s Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Wahlberg","sequence":"additional","affiliation":[{"name":"Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences (HMV), Link\u00f6ping University, Link\u00f6ping, 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