{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:24:48Z","timestamp":1780590288634,"version":"3.54.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Atherosclerosis involves vascular endothelial damage and lipid metabolism disorder, which is closely related to the occurrence and development of diabetic kidney disease (DKD). However, studies on non-high albuminuria DKD (NHADKD) with an albumin to creatinine ratio (ACR) &lt;30\u2009mg\/g are rare. This study is to investigate the relationship between atherogenic factors and the occurrence of NHADKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Serum lipid indicators, lipoprotein-associated phospholipase A2 (Lip-PLA2) and homocysteine levels were measured in 1116 subjects to analyze their relationship with NHADKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among all subjects, Lip-PLA2 had the closest but relatively weak correlation with ACR ( r\u2009=\u20090.297, p\u2009&lt;\u20090.001) and only homocysteine was moderately correlated with eGFR ( r\u2009=\u2009\u22120.465, p\u2009&lt;\u20090.001). However, in patients with NHADKD, these atherosclerotic factors were weakly correlated or uncorrelated with eGFR (max. | r|\u2009=\u20090.247). Stratified risk analysis showed that when ACR was &lt;10\u2009mg\/g, homocysteine [OR\u2009=\u20096.97(4.07\u201311.95)], total cholesterol (total-Chol) [OR\u2009=\u20096.04(3.03\u201312.04)], and high-density lipoprotein cholesterol (HDL-Chol) [OR\u2009=\u20095.09(2.99\u20138.64)] were risk factors for NHADKD. There was no significant difference of OR between these three factors ( Z\u2009=\u20090.430\u20131.044, all p\u2009&gt;\u20090.05). When ACR was \u2a7e10mg\/g, homocysteine [OR\u2009=\u200917.26(9.67\u201330.82)] and total-Chol [OR\u2009=\u20095.63(2.95\u201310.76)] were risk factors for NHADKD, and OR\n                      <jats:sub>homocysteine<\/jats:sub>\n                      was significantly higher than OR\n                      <jats:sub>total-Chol<\/jats:sub>\n                      ( Z\u2009=\u20093.023, p\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The occurrence of NHADKD may be related to the levels of homocysteine, total-Chol, HDL-Chol, and Lip-PLA2 in blood. Among them, homocysteine may be most closely related to NHADKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164121992524","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T06:32:47Z","timestamp":1613197967000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Vascular inflammation, atherosclerosis, and lipid metabolism and the occurrence of non-high albuminuria diabetic kidney disease: A cross-sectional study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-1228","authenticated-orcid":false,"given":"Yuwei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pidu District People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"bibr1-1479164121992524","doi-asserted-by":"publisher","DOI":"10.26442\/terarkh201890104-98"},{"key":"bibr2-1479164121992524","volume":"43","author":"American Diabetes Association","year":"2020","journal-title":"Diabetes Care"},{"key":"bibr3-1479164121992524","first-page":"84","volume-title":"Am J Kidney Dis","volume":"75","author":"Levey AS","year":"2019"},{"key":"bibr4-1479164121992524","first-page":"150","volume":"3","author":"Kidney Disease: Improving 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