{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:39Z","timestamp":1790009679516,"version":"4.0.1"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare clinical outcomes in diabetic patients with heart failure managed by insulin with those managed by non-insulin (oral hypoglycemic agents and\/or lifestyle modification) based therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed and Scopus databases were searched for studies conducted on diabetic patients with heart failure. Studies were to compare outcomes of patients managed by insulin versus non-insulin therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>15 studies were included. Compared to those who were managed using non-insulin therapy, insulin-treated patients had increased risk of all-cause mortality (RR 1.46, 95% CI: 1.14, 1.88) and cardiovascular specific mortality (RR 1.62, 95% CI: 1.33, 1.96). Those managed using insulin also had increased risk of hospitalization (RR 1.45, 95% CI: 1.09, 1.93) and readmission (RR 1.49, 95% CI: 1.32, 1.67). There was no additional risk for stroke (RR 1.07, 95% CI: 0.91, 1.27) or myocardial infarction (MI) (RR 1.10, 95% CI: 0.96, 1.27) between the two groups of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Receipt of insulin among diabetic patients with heart failure was associated with an increased risk of mortality, hospitalization and readmission compared to management using oral hypoglycemic agents and\/or lifestyle modification. Such patients should be closely monitored for any adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641221093175","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:01:28Z","timestamp":1652252488000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of insulin therapy on outcomes of diabetic patients with heart failure: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"19","author":[{"given":"Jingxing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Emergency Intensive Care Medicine, Changxing People\u2019s Hospital, Changxing County, Huzhou City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-2715","authenticated-orcid":false,"given":"Xinhua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changxing People\u2019s Hospital, Changxing County, Huzhou City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"bibr1-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71908-9"},{"key":"bibr2-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"bibr3-14791641221093175","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"bibr4-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12005"},{"key":"bibr5-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311371"},{"key":"bibr6-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn153"},{"key":"bibr7-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01026-3"},{"key":"bibr8-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.10.024"},{"key":"bibr9-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-2-1"},{"key":"bibr10-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.019"},{"key":"bibr11-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008476"},{"key":"bibr12-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000691"},{"key":"bibr13-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1347"},{"key":"bibr14-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.19.2271"},{"key":"bibr15-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.033"},{"key":"bibr16-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000045671.62860.98"},{"key":"bibr17-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.003"},{"key":"bibr18-14791641221093175","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S318"},{"key":"bibr19-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252649"},{"key":"bibr20-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00390.2012"},{"key":"bibr21-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2012.03.001"},{"key":"bibr22-14791641221093175","unstructured":"PRISMA. Transparent Reporting of systematic Reviews and meta-analyses. Columbia, SC: PRISMA. http:\/\/www.prisma-statement.org\/"},{"key":"bibr23-14791641221093175","volume-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis","volume":"21","author":"Wells G"},{"key":"bibr24-14791641221093175","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series","volume":"674","author":"Higgins JP"},{"key":"bibr25-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"bibr26-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.11.022"},{"key":"bibr27-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12944"},{"key":"bibr28-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1535"},{"key":"bibr29-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01370-y"},{"key":"bibr30-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.08.020"},{"key":"bibr31-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01206.x"},{"key":"bibr32-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.07.005"},{"key":"bibr33-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-007959"},{"key":"bibr34-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1146"},{"key":"bibr35-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs153"},{"key":"bibr36-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.04.079"},{"key":"bibr37-14791641221093175","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2227"},{"key":"bibr38-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.20.2273"},{"key":"bibr39-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi555"},{"key":"bibr40-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154542.13412.B1"},{"key":"bibr41-14791641221093175","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0697"},{"key":"bibr42-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11728"},{"key":"bibr43-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.9400"},{"key":"bibr44-14791641221093175","doi-asserted-by":"publisher","DOI":"10.2337\/dcS15-3014"},{"key":"bibr45-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.008"},{"key":"bibr46-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022281"},{"key":"bibr47-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.09.001"},{"key":"bibr48-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.013"},{"key":"bibr49-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1191955"},{"key":"bibr50-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70027-5"},{"key":"bibr51-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-3-10"},{"key":"bibr52-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9810-6"},{"key":"bibr53-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-07-0484"},{"key":"bibr54-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-011-0165-4"},{"key":"bibr55-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/340570"},{"key":"bibr56-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203858"},{"key":"bibr57-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"bibr58-14791641221093175","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805796"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641221093175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14791641221093175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641221093175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:19:49Z","timestamp":1777400389000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14791641221093175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/14791641221093175"],"URL":"https:\/\/doi.org\/10.1177\/14791641221093175","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]},"article-number":"14791641221093175"}}