{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:41:03Z","timestamp":1779349263098,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Graduate School for Health Sciences, University of Bern"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>The aim of the study was to examine the predictive value of coronary computed tomographic angiography (CCTA) and coronary artery calcium score (CACS) on 1-year all-cause mortality in type 2 diabetes (T2D) patients with peripheral artery disease (PAD) undergoing partial foot amputations (PFA).<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 \u00b1 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a period of 1 year follow-up, a total of 35 (17.6%) participants died. The area under ROC curve to predict mortality for the CACS was 0.835 (95% CI:0.769\u20130.900), for CCTA 0.858 (95% CI:0.788\u20130.927). After adjustment for confounders, compared to no-stenosis on CCTA (reference), the risk of all-cause mortality in non-obstructive coronary atery disease (CAD) increased (HR = 1.38, 95% CI [0.75\u201312.86], p = .284), 1-vessel obstructive CAD (HR = 8.13, 95% CI [0.87\u201375.88], p = .066), 2-vessels (HR = 10.94, 95% CI [1.03\u2013115.8], p = .047), and 3-vessels (HR = 45.73, 95% CI [4.6\u2013454.7], p = .001) respectively. Increasing levels of CACS tended to be associated with increased risk of all-cause mortality (HR = 1.002, 95% CI [1.0\u20131.003], p = .061). 61\/95 patients with obstructive CAD underwent coronary revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coronary artery calcium score and CCTA have a high predictive value for 1-year all-cause mortality in T2D patients undergoing minor amputations and may be considered for preoperative risk assessment allowing timely preventive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641221125190","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T03:46:06Z","timestamp":1665546366000},"page":"147916412211251","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-0627","authenticated-orcid":false,"given":"Evgeniya","family":"Shalaeva","sequence":"first","affiliation":[{"name":"Graduate School for Health Sciences, University of Bern, Bern, Switzerland"},{"name":"Tashkent Medical Academy, Tashkent, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjola","family":"Bano","sequence":"additional","affiliation":[{"name":"Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland"},{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulugbek","family":"Kasimov","sequence":"additional","affiliation":[{"name":"Tashkent Medical Academy, Tashkent, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakhtiyor","family":"Janabaev","sequence":"additional","affiliation":[{"name":"Tashkent Medical Academy, Tashkent, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-3599","authenticated-orcid":false,"given":"Iris","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Angiology, University Hospital Bern, Swiss Cardiovascular Centre, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Laimer","sequence":"additional","affiliation":[{"name":"Clinic for Diabetology, Endocrinology, Nutrition and Metabolism, University Hospital Bern, Bern 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