{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:24:02Z","timestamp":1786389842171,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical health Science and Technology project of Zhejiang Province","award":["2021KY1062"],"award-info":[{"award-number":["2021KY1062"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>MicroRNAs plays important roles in the progression of diabetic nephropathy (DN) and podocyte injury. This study aimed to investigate the role and regulation mechanism of miR-1187 during the development of DN and podocyte injury. The content of miR-1187 in podocytes was up-regulated under high glucose (HG) treatment and increased in kidney tissue of db\/db mice (DN model mice) compared with control db\/m mice. The administration of miR-1187 inhibitor could decrease podocyte apoptosis induced by HG and attenuate the decline in renal function and reduce proteinuria as well as glomerular apoptosis in db\/db mice. Mechanistically, miR-1187 could inhibit the autophagy level in HG-exposed podocytes and glomerulus of DN mice. Moreover, miR-1187 inhibitor could reduce HG-stimulated podocyte injury and autophagy flux inhibition. The mechanism may depend on autophagy. In conclusion, targeting miR-1187 may be a new therapeutic target for improving the high glucose damage of podocytes and the progression of DN.<\/jats:p>","DOI":"10.1177\/14791641231172139","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:46:08Z","timestamp":1684543568000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["miR-1187 induces podocyte injury and diabetic nephropathy through autophagy"],"prefix":"10.1177","volume":"20","author":[{"given":"Bin","family":"Chen","sequence":"first","affiliation":[{"name":"Medical College of Soochow University, Suzhou, China"},{"name":"Ningbo Zhenhai People\u2019s Hospital (Ningbo No.7 Hospital), Zhejiang, 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