{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:29:13Z","timestamp":1793276953867,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001439"],"award-info":[{"award-number":["UL1 TR001439"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health and Human Services, Health Resources and Services Administration","award":["1 D34HP49234\u201001\u201000"],"award-info":[{"award-number":["1 D34HP49234\u201001\u201000"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diabetes related foot ulcers (DFUs) are common complications of type 2 diabetes mellitus (T2DM), affecting 15\u201325% of individuals living with diabetes and significantly contributing to healthcare costs ($9\u201313 billion annually in the U.S.). Without effective management, these wounds often lead to severe outcomes like amputations. This study aims to examine the association of semaglutide on DFU management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study utilized TriNetX US Research Network data to assess the impact of semaglutide, a GLP-1 receptor agonist, on DFU outcomes between 2013 and 2023. The study compared outcomes between semaglutide users with DFU (Cohort A,\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 6329) and non-users with DFU (Cohort B,\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 118,821) across 64 healthcare organizations. We matched participants by age, gender, race, and ethnicity; however, we excluded patients with certain co-morbidities. Statistical analysis, such as chi-square analysis and risk ratio, using TriNetX software evaluated different complication outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Semaglutide users with DFU demonstrated lower relative risks for complications compared to non-users. Within 1\u00a0year, semaglutide users were associated with lower relative risks for wound healing complications (0.19% vs 0.38%), chronic non-healing wounds (0.75% vs 1.23%), chronic pain (4.44% vs 8.06%), wound care (2.42% vs 4.86%), wound dehiscence (0.26% vs 0.56%), and amputation (2.34% vs 5.21%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .05). Similar trends persisted over 5\u00a0years. While these findings highlight potential benefits of semaglutide with patients with DFU, causation cannot be inferred due to the study\u2019s observational design.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semaglutide use was associated with favorable outcomes in patients with diabetes-related foot ulcers, including reductions in wound-related complications. While these findings suggest potential benefits of semaglutide as an adjunct in DFU management, further research is needed to confirm these associations and to better understand the mechanisms involved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641251322909","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:42:51Z","timestamp":1741876971000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["The impact of semaglutide on wound healing in diabetes related foot ulcer patients: A TriNetX database study"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4785-2011","authenticated-orcid":false,"given":"Joshua E","family":"Lewis","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8116-4290","authenticated-orcid":false,"given":"Diana K","family":"Omenge","sequence":"additional","affiliation":[{"name":"University of Houston School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3082-8986","authenticated-orcid":false,"given":"Amani R","family":"Patterson","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8776-5941","authenticated-orcid":false,"given":"Ogechukwu","family":"Anwaegbu","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nangah N","family":"Tabukum","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Jimmie E","family":"Lewis","sequence":"additional","affiliation":[{"name":"Barry University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i1.27"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/life12071054"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2075"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33484"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14841"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2020.1798162"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01499-w"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31982"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.12.017"},{"key":"e_1_3_5_15_2","unstructured":"2025 ICD-10-CM Diagnosis Code E11.621: type 2 diabetes mellitus with foot ulcer. https:\/\/www.icd10data.com\/ICD10CM\/Codes\/E00-E89\/E08-E13\/E11-\/E11.621?utm_source=chatgpt.com (Accessed January 3 2025)."},{"key":"e_1_3_5_16_2","volume-title":"Diabetic foot ulcer coding - diabetes awareness month","author":"CPMA JDL DPM, FASPS, MAPWCA, CPC","unstructured":"CPMA JDL DPM, FASPS, MAPWCA, CPC. Diabetic foot ulcer coding - diabetes awareness month. Intellicure, November 3, 2021. https:\/\/www.intellicure.com\/blog\/diabetic-foot-ulcer-coding\/ (Accessed 3 January 2025)."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14863"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.12.018"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i6.827"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147930"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010564"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/UPO9781922064004.027"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-017-0081-y"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1014"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1106"},{"key":"e_1_3_5_26_2","volume-title":"Public health considerations regarding obesity","author":"Tiwari A","year":"2024","unstructured":"Tiwari A, Balasundaram P. 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