{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:05:50Z","timestamp":1777557950343,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The SUSTAIN-6 trial showed the cardiovascular disease (CVD) benefits of semaglutide among patients with type 2 diabetes mellitus (T2DM). We estimated the US population eligibility and preventable CVD events from semaglutide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>US adults with T2DM were selected from the National Health and Nutrition Examination Survey 2011\u20132020 based on SUSTAIN-6 eligibility criteria. We estimated composite and secondary CVD events from SUSTAIN-6 treated and placebo published event rates multiplied by the weighted US eligible population, the difference being the number of preventable events which was then divided by 2.1\u00a0years to provide annualized estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4755 (projected to 33.6\u00a0million [M]) adults with T2DM, 1132 (6.9\u00a0million) fit SUSTAIN-6 criteria. Compared to SUSTAIN-6, our sample more likely had female and black patients, shorter diabetes duration, and was less likely with prior CVD. We estimated 75,681 primary outcome CVD events, 128,329 expanded composite CVD events, 72,390 combined nonfatal MI, nonfatal stroke, and all-cause deaths, 36,195 non-fatal stroke events, 85,552 revascularizations, and 75,681 cases of nephropathy could be prevented annually if eligible T2DM subjects were on semaglutide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semaglutide may prevent over 75,000 CVD events annually if provided to eligible T2DM US adults. Efforts to improve use of these therapies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641251376551","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:51:28Z","timestamp":1757055088000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["US eligibility and preventable cardiovascular disease events from semaglutide in type 2 diabetes"],"prefix":"10.1177","volume":"22","author":[{"given":"Hridhay","family":"Karthikeyan","sequence":"first","affiliation":[{"name":"Mary and Steve Wen Cardiovascular Division, School of Medicine, University of California, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Fan","sequence":"additional","affiliation":[{"name":"Mary and Steve Wen Cardiovascular Division, School of Medicine, University of California, Irvine, CA, USA"},{"name":"Center for Global Cardiometabolic Health and Nutrition, University of California, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7324","authenticated-orcid":false,"given":"Nathan D.","family":"Wong","sequence":"additional","affiliation":[{"name":"Mary and Steve Wen Cardiovascular Division, School of Medicine, University of California, Irvine, CA, USA"},{"name":"Center for Global Cardiometabolic Health and Nutrition, University of California, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"International Diabetes Federation. IDF diabetes atlas. 2021."},{"key":"e_1_3_5_3_2","volume-title":"National diabetes statistics report, 2023","author":"Centers for Disease Control and Prevention","year":"2024","unstructured":"Centers for Disease Control and Prevention. National diabetes statistics report, 2023. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services, 2024."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s231"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32261-X"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_3_5_11_2","unstructured":"NHANES 2007-2008 laboratory procedures manual. Hyattsville MD: US Department of Health and Human Services Centers for Disease Control and Prevention."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/XCE.0000000000000189"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-07032-7"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-023-07488-3"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-024-07583-z"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1997.0190"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-022-07403-2"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2023.05.002"}],"container-title":["Diabetes &amp; Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641251376551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14791641251376551","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641251376551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:16Z","timestamp":1777400416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14791641251376551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/14791641251376551"],"URL":"https:\/\/doi.org\/10.1177\/14791641251376551","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"article-number":"14791641251376551"}}