{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:05:46Z","timestamp":1777557946036,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes-related foot ulcers (DFUs), often complicated by peripheral arterial disease (PAD), remain a major therapeutic challenge. In patients unsuitable for revascularization, alternative treatments are essential. This study is the first to evaluate bipolar radiofrequency (RF) ablation as part of lumbar sympathetic block (LSB) for enhancing wound healing in DFU patients with critical limb ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 31 DFU patients with severe PAD who were not candidates for revascularization. Group 1 (n = 18) received LSB with bipolar RF plus medical care; Group 2 (n = 13) received medical care alone. Wound healing, amputation rates, pain scores (NRS, DN4), and complications were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complete wound healing was significantly higher in Group 1 (55.5%) than in Group 2 (15.3%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.031). Amputation was required in 23.1% of Group 2 patients, while none occurred in Group 1 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.063). Group 1 showed significant reductions in DN4 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0057) and NRS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0013) at 6\u00a0months. No complications related to LSB were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LSB with bipolar RF ablation is a safe, potentially effective option for DFU patients with PAD not eligible for revascularization. It significantly improves wound healing and pain outcomes. Larger prospective studies are needed to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641251395221","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T06:50:12Z","timestamp":1763103012000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel approach to diabetes-related foot ulcers\/disease: First report of bipolar conventional RF lumbar sympathetic block"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-1975","authenticated-orcid":false,"given":"\u00c7i\u011fdem","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Mersin City Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuz Ka\u011fan","family":"Demirta\u015f","sequence":"additional","affiliation":[{"name":"Etlik City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harun","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Mersin City Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"G\u00f6kalp","sequence":"additional","affiliation":[{"name":"Tatvan State Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i8.1684"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3276"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12440"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1596"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12404"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1816"},{"key":"e_1_3_4_10_2","volume-title":"Peripheral vascular bypass. I\u00e7inde: Statpearls [Internet]","author":"Young J","year":"2025","unstructured":"Young J, Lotfollahzadeh S, Patel SK. Peripheral vascular bypass. I\u00e7inde: Statpearls [Internet]. StatPearls Publishing, 2025. Eri\u015fim adresi. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499827\/"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013440"},{"key":"e_1_3_4_12_2","volume-title":"Sympathetic nerve block. I\u00e7inde: statpearls","author":"Doroshenko M","year":"2025","unstructured":"Doroshenko M, Turkot O, Dua A, et al. Sympathetic nerve block. I\u00e7inde: statpearls. StatPearls Publishing, 2025. Eri\u015fim adresi. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557637\/"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2015.03.007"},{"issue":"6","key":"e_1_3_4_14_2","first-page":"e61755","article-title":"Lumbar sympathetic block leading to increased arterial diameter and blood flow: a mechanism of therapeutic benefit","volume":"16","author":"Dickey Z","year":"2024","unstructured":"Dickey Z, Sharma N. Lumbar sympathetic block leading to increased arterial diameter and blood flow: a mechanism of therapeutic benefit. Cureus 2024; 16(6): e61755. Eri\u015fim adresi. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11227424\/","journal-title":"Cureus"},{"issue":"4","key":"e_1_3_4_15_2","first-page":"442","article-title":"Efficacy of the lumbar sympathetic ganglion block in lower limb pain and its application prospects during the perioperative period. Ibrain [\u0130nternet]","volume":"8","author":"Zhang J","unstructured":"Zhang J, Deng Y, Geng M. Efficacy of the lumbar sympathetic ganglion block in lower limb pain and its application prospects during the perioperative period. Ibrain [\u0130nternet]. 09 Ekim; 8(4): 442\u2013452. Eri\u015fim adresi. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10529158\/","journal-title":"09 Ekim"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13323"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1021374"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v11.i9.391"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2016.01.012"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60050682"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.1.72"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2010.04.008"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00400.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00918-7"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199103000-00012"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.10.050"},{"key":"e_1_3_4_27_2","unstructured":"Alp Yent\u00fcr MDEF. Complications of lumbar sympathetic block. I\u00e7inde: complications of pain-relieving procedures. John Wiley & Sons Ltd."},{"issue":"1","key":"e_1_3_4_28_2","first-page":"54","article-title":"Psoas hematoma with lumbar artery pseudoaneurysm after lumbar sympathetic plexus block accompanying voiding difficulty","volume":"7","author":"Lee EK","year":"2016","unstructured":"Lee EK, Sim WS, Park JY, et al. Psoas hematoma with lumbar artery pseudoaneurysm after lumbar sympathetic plexus block accompanying voiding difficulty. International Journal of Pain. 2016; 7(1): 54\u201358.","journal-title":"International Journal of Pain"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojanes.2014.44015"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2015.18.E89"}],"updated-by":[{"DOI":"10.1177\/14791641261438547","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000}}],"container-title":["Diabetes &amp; Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641251395221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14791641251395221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641251395221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:17Z","timestamp":1777400417000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14791641251395221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/14791641251395221"],"URL":"https:\/\/doi.org\/10.1177\/14791641251395221","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"14791641251395221"}}