{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:54Z","timestamp":1784937834776,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to verify the value of miR-143-3p in diabetic cardiomyopathy (DCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ROC curve, correlation analysis, and multivariate Logistic regression analysis assessed the diagnostic value, association with DCM, and DCM risk factors. Bioinformatic analysis predicted the downstream targets of miR-143-3p. Dula-luciferase reporter assay validated the interaction between miR-143-3p and ERBB3. In vitro high glucose (HG)-stimulated cardiomyocyte (AC16) injury was employed to clarify the mechanism of the miR-143-3p\/ERBB3 axis in DCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Upregulation of miR-143-3p was observed in the DM group and further elevated in the DCM group compared with healthy individuals. The upregulated miR-143-3p expression distinguished subjects with DM from healthy individuals and diagnosed subjects with DCM from DM. MiR-143-3p expression was associated with blood glucose, myocardial injury, and cardiac function of DCM, and predicted the risk for DCM development. In vitro, the inhibition of miR-143-3p attenuated HG-induced AC16 cell injury through improving cell proliferation, suppressing apoptosis, inflammation, oxidative stress, and the release of myocardial enzymes by upregulating the ERBB3 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Upregulation of miR-143-3p showed a diagnostic potential for DCM and predicted the progression of DCM. In vitro, miR-143-3p promoted HG-induced cardiomyocyte injury by targeting ERBB3, which might provide novel insights for DCM clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641261454501","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:43:36Z","timestamp":1784731416000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR-143-3p serves as a novel biomarker for diabetic cardiomyopathy and is involved in regulating high glucose-induced cardiomyocyte injury"],"prefix":"10.1177","volume":"23","author":[{"given":"Zhengnan","family":"Zhang","sequence":"first","affiliation":[{"name":"Geriatric Hospital Affiliated to Wuhan University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuxi Hospital of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Huaihe Hospital of Henan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8115-4198","authenticated-orcid":false,"given":"Yang","family":"Bian","sequence":"additional","affiliation":[{"name":"Baoji Hospital of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Taikang Tongji (Wuhan) Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02181-7"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.283"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.01.003"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2019.02.003"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0519-5"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-016-0216-y"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2016.06.001"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021037533"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177956"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11774"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110944"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04473-6"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14241995"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104346"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107515"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S011"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0201-8"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.25-91"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060661"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03522-4"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.53419"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01986-2"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163682"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19138-4"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2018.01027"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123916"},{"key":"e_1_3_7_30_2","article-title":"The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy","volume":"17","author":"Wang S","year":"2016","unstructured":"Wang S, Ding L, Ji H, et al. 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