{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:40:06Z","timestamp":1793907606620,"version":"4.8.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Children's Hospital of Pittsburgh of the UPMC Health System"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) is a recognized cardiometabolic risk factor in adults, but its relevance to early vascular remodeling in youth with type 1 diabetes (T1D) remains unclear. We evaluated the independent associations of hepatic fat and body composition with early structural vascular remodeling in youth with T1D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 49 late-pubertal youth with T1D (mean age 16.1\u00b12.6 years; duration 7.5\u00b14.3 years). Hepatic fat was quantified using MRI\u2013proton density fat fraction (PDFF), while body composition and estimated insulin sensitivity (eIS) were assessed using dual-energy X-ray absorptiometry and a validated pediatric equation. Carotid intima\u2013media thickness (cIMT), measured by ultrasound, served as the primary outcome. Hierarchical linear regression assessed independent associations after adjustment for age, sex, and diabetes duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean hepatic fat was 1.87\u00b11.22%, with no participants meeting criteria for steatosis. Hepatic fat, eIS, and diabetes duration were not associated with cIMT. Lean body mass was the primary independent associate of cIMT (\u03b2=0.44, p=0.02). Although eIS was strongly associated with waist circumference (r=\u22120.76, p&lt;0.001), neither variable was associated with cIMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this sub-steatotic cohort, cIMT was primarily associated with lean body mass, reflecting physiologic growth, while central adiposity was associated with metabolic dysfunction but not vascular structure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641261470422","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:23:37Z","timestamp":1784121817000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Body composition rather than liver fat associates with carotid Intima\u2013Media thickness in youth with type 1 diabetes"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3759-2778","authenticated-orcid":false,"given":"Emir","family":"Tas","sequence":"first","affiliation":[{"name":"UPMC Children\u2019s Hospital of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memduha","family":"Gumus","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"UPMC Children\u2019s Hospital of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Movva","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Mendizabal","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"UPMC Children\u2019s Hospital of 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