{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:47:27Z","timestamp":1785754047378,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>ABO groups impact macroangiopathy risk in T2D. It is unknown whether such modulation extends to microvascular complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Single-centre cross-sectional study including 1,006 T2D patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of overall microangiopathy was 51%. No significant differences (ANOVA) were observed between ABO groups in terms of age, sex, diabetes duration, BMI, hypertension, chronic kidney disease or diabetic foot. Insulin sensitivity and the hyperbolic HOMA product [BxS] were lower among non-O groups (-20% and -14%, respectively; p 0.001 and 0.013), while HbA1c and lifetime hyperglycaemia exposure were higher (+5% and +25%, respectively; p 0.006 and 0.002). Overall microangiopathy was more prevalent among non-O patients (+23%; p 0.001), as was neuropathy (+44%; p 0.005). Differences across ABO groups were significant for overall microangiopathy (p 0.009) and neuropathy (p 0.027) (ANOVA). In multivariate analysis, group A (vs O) was associated with overall microangiopathy (OR=1.62; 95%CI: 1.18\u20132.22; p 0.003) after adjustment for diabetes duration, HbA1c, smoking, remnant-C and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T2D patients of blood group A have increased frequency of overall microangiopathy, regardless of other risk factors. Group O subjects exhibit better glucose homeostasis, with better insulin sensitivity and \u03b2-cell function. The ABO system therefore impacts both glucose homeostasis and microvascular susceptibility in T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641261474101","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:19:35Z","timestamp":1785446375000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between non-O blood groups and microvascular risk in type 2 diabetes"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9746-4489","authenticated-orcid":false,"given":"Fabian O.","family":"Lurquin","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise L.","family":"Petit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Oriot","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie-Diab\u00e9tologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie A.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel P.","family":"Hermans","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03423-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02669-w"},{"issue":"2","key":"e_1_3_4_4_2","first-page":"237","article-title":"Association of ABO and Rh blood groups with type 2 diabetes mellitus","volume":"20","author":"Meo SA","year":"2016","unstructured":"Meo SA, Rouq FA, Suraya F, et al. Association of ABO and Rh blood groups with type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci 2016; 20(2): 237\u2013242.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"e_1_3_4_5_2","first-page":"444","article-title":"Risk factors for micro- and macroangiopathic complications in type 2 diabetes: lack of association with acetylator phenotype, chlorpropamide alcohol flush and ABO and Rh blood groups","volume":"13","author":"Pontiroli AE","year":"1987","unstructured":"Pontiroli AE, Calderara A, Bonisolli L, et al. Risk factors for micro- and macroangiopathic complications in type 2 diabetes: lack of association with acetylator phenotype, chlorpropamide alcohol flush and ABO and Rh blood groups. Diabete Metab 1987; 13(4): 444\u2013449.","journal-title":"Diabete Metab"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.25048\/tudod.1359676"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.15406\/jdmdc.2017.05.00130"},{"key":"e_1_3_4_8_2","first-page":"341","article-title":"The correlation of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus with or without microvascular complications","author":"Elavala P","year":"2025","unstructured":"Elavala P, Chaitra MC. The correlation of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus with or without microvascular complications. South Eastern European Journal of Public Healt 2025: 341\u2013346.","journal-title":"South Eastern European Journal of Public Healt"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20192084"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2025.2524239"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02582069"},{"issue":"2","key":"e_1_3_4_12_2","first-page":"57","article-title":"Association of ABO Gene rs2073823 Polymorphism with Microvascular Complications, sP-Selectin Levels and Lipid Profile in Type 2 Diabetes","volume":"22","author":"Mohammed HR","year":"2025","unstructured":"Mohammed HR, Othman RB, Hatef ZS, et al. Association of ABO Gene rs2073823 Polymorphism with Microvascular Complications, sP-Selectin Levels and Lipid Profile in Type 2 Diabetes. Curr Diabetes Rev 2025; 22(2): 57\u201367.","journal-title":"Curr Diabetes Rev"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-024-03577-5"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1072288"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.960682"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.192971"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2007.019"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.08.029"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0564-9"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00274-6"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015044"},{"issue":"4","key":"e_1_3_4_22_2","first-page":"491","article-title":"Beyond immunohaematology: the role of the ABO blood group in human diseases","volume":"11","author":"Liumbruno GM","year":"2013","unstructured":"Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus 2013; 11(4): 491\u2013499. https:\/\/doi.org\/10.2450\/2013.0152-13","journal-title":"Blood Transfus"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00975.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.05.049"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1359255"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-1619"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.016"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00188.2022"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055396"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032782"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-122945"},{"issue":"4","key":"e_1_3_4_32_2","first-page":"327","article-title":"Von Willebrand factor in diabetic angiopathy","volume":"24","author":"Kessler L","year":"1998","unstructured":"Kessler L, Wiesel ML, Attali P, et al. Von Willebrand factor in diabetic angiopathy. Diabetes Metab 1998; 24(4): 327\u2013336.","journal-title":"Diabetes Metab"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418350"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00608.x"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.731658"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2024.1485420"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132784"}],"container-title":["Diabetes &amp; Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641261474101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14791641261474101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641261474101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:17:40Z","timestamp":1785752260000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14791641261474101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/14791641261474101"],"URL":"https:\/\/doi.org\/10.1177\/14791641261474101","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"14791641261474101"}}