{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:15:14Z","timestamp":1788174914078,"version":"build-2803163510"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Joint Research Foundation of Gansu Province","award":["24JRRA918"],"award-info":[{"award-number":["24JRRA918"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270889"],"award-info":[{"award-number":["81270889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960155"],"award-info":[{"award-number":["81960155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360161"],"award-info":[{"award-number":["82360161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology planning project of Lanzhou City","award":["2022-3-46"],"award-info":[{"award-number":["2022-3-46"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atherosclerotic cardiovascular disease (ASCVD) is one of the common complications in patients with type 2 diabetes mellitus (T2DM). Thyroid hormones affect cardiovascular function through multiple pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the relationships between impaired thyroid hormone sensitivity and the 10-year risk of ASCVD in euthyroid patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>899 patients with T2DM were divided into three groups according to the different ASCVD risk levels, the difference of thyroid hormone sensitivity indices [Parametric Thyroid Feedback Quantile-based Index (PTFQI), Thyroid Feedback Quantile-based Index (TFQI), Thyroid Stimulating Hormone Index (TSHI), Serum-Free triiodothyronine to Free thyroxine (FT3\/FT4) ratio, and Thyrotropin Thyroxine Resistance Index (TT4RI)] between three groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As the 10-year ASCVD risk grade increased, TT4RI level showed a gradually rising trend, while FT3\/FT4 ratio exhibited a decreasing trend (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). PTFQI, TFQI, TSHI, and TT4RI were positively, and FT3\/FT4 was negatively correlated with ASCVD risk (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Thyroid hormone sensitivity indicators had a linear dose-response relationships with ASCVD risk. As the levels of PTFQI, TFQI, TSHI, and TT4RI increase and the level of FT3\/FT4 decreases, the ASCVD risk showed an upward trend.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To patients with T2DM, impaired thyroid hormone sensitivity is associated with ASCVD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641261484963","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:03:10Z","timestamp":1787929390000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The correlation between impaired thyroid hormone sensitivity and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score in patients with type 2 diabetes mellitus"],"prefix":"10.1177","volume":"23","author":[{"given":"Yuqian","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaner","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefan","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junni","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-4454","authenticated-orcid":false,"given":"Jingfang","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Lanzhou University"},{"name":"The First Hospital of Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-025-02667-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S305156"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.35.2.260"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehag248"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14152"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1410"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13003"},{"issue":"5","key":"e_1_3_3_10_2","first-page":"1608","article-title":"Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity","volume":"82","author":"Yagi H","year":"1997","unstructured":"Yagi H, Pohlenz J, Hayashi Y, et al. Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity. J Clin Endocrinol Metab 1997; 82(5): 1608\u20131614. https:\/\/doi.org\/10.1210\/jcem.82.5.3945","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13345"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022367"}],"container-title":["Diabetes &amp; Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641261484963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14791641261484963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14791641261484963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:19:58Z","timestamp":1788171598000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14791641261484963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/14791641261484963"],"URL":"https:\/\/doi.org\/10.1177\/14791641261484963","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"14791641261484963"}}