{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:33:33Z","timestamp":1793010813821,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Vascular Disease Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Although allopurinol is used for urate-lowering therapy, its effect on myocardial infarction risk remains unclear. This study assessed the association between allopurinol use and myocardial infarction in adults with gout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis was conducted following PROSPERO registration (CRD420261305257). PubMed, Scopus, and Web of Science were searched from inception to January 2026. Observational studies of adults with confirmed gout that reported adjusted hazard ratios (HRs) for myocardial infarction and separately identifiable allopurinol exposure were included. Pooled estimates were calculated using an inverse-variance random-effects model with the Paule\u2013Mandel estimator. Robustness was assessed through leave-one-out, active-comparator, and Hartung\u2013Knapp sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four retrospective cohort studies met the revised eligibility criteria. In the primary random-effects analysis, allopurinol use was associated with a lower risk of myocardial infarction (HR 0.84; 95% CI 0.76\u20130.94; I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%). However, the association was not statistically significant after excluding the study contributing the greatest weight (HR 1.04; 95% CI 0.79\u20131.36), when restricted to active comparators (HR 1.04; 95% CI 0.79\u20131.36), or using the Hartung\u2013Knapp adjustment (HR 0.84; 95% CI 0.71\u20131.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Allopurinol therapy was associated with a modest but significant reduction in myocardial infarction risk in adults with gout.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14791641261495574","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:39:32Z","timestamp":1792777172000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of myocardial infarction in adults with gout treated with allopurinol: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-7126","authenticated-orcid":false,"given":"Jhair Alexander","family":"Leon-Rodriguez","sequence":"first","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Leonidas","family":"Agreda-Gil","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Stalin","family":"Diaz-Rimarachin","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Iv\u00e1n","family":"Mu\u00f1oz-Tasilla","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly Lisde","family":"S\u00e1nchez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Mond\u00e9jar-Barrios","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.04.008"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00804-5"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.12.004"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd12040148"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.011"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/publications14010004"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7665"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_3_5_13_2","first-page":"153","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi S","year":"2019","unstructured":"Balduzzi S, R\u00fccker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. 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