{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:55:01Z","timestamp":1793368501308,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Inherited neuromuscular disorders inevitably result in severe lung volume restriction associated with high morbidity and mortality. The aim of this retrospective study was to evaluate the long-term effects of the regular use of mechanical insufflation\/exsufflation on the course of the vital capacity. This retrospective data analysis included 21 patients (16.1 \u00b1 6.5 years) with neuromuscular disorders and severe lung volume restriction using nocturnal noninvasive ventilation. The patients were advised to regularly use the mechanical insufflation\/exsufflation twice a day for 10 minutes applying sets of three insufflation\/exsufflation breath via face mask irrespective of respiratory tract infection. Data on the course of vital capacity were collected 2 years prior and 2 years after the introduction of regular use of mechanical insufflation\/exsufflation. Before the introduction of mechanical insufflation\/exsufflation vital capacity decreased from 0.71 \u00b1 0.38 L to 0.50 \u00b1 0.24 L in the last year and from 0.88 \u00b1 0.45 L to 0.71 \u00b1 0.38 L in the next to last year. In the first year, after regular use of mechanical insufflation\/exsufflation vital capacity significantly increased by 28% (from 0.50 L to 0.64 L)\u2014after the second year the vital capacity increase remained stable (0.64 vs. 0.65 L). These data suggest that the regular use of mechanical insufflation\/exsufflation improves vital capacity in patients with neuromuscular disorders and severe lung volume restriction.<\/jats:p>","DOI":"10.1177\/1479972314562209","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T23:58:45Z","timestamp":1417651125000},"page":"31-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Mechanical insufflation\/exsufflation improves vital capacity in neuromuscular disorders"],"prefix":"10.1177","volume":"12","author":[{"given":"Florian","family":"Stehling","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology and Sleep Medicine, University of Duisburg-Essen, Children\u2019s Hospital, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Bouikidis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Sleep Medicine, University of Duisburg-Essen, Children\u2019s Hospital, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, University of Duisburg-Essen, Children\u2019s Hospital, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Mellies","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Sleep Medicine, University of Duisburg-Essen, Children\u2019s Hospital, Essen, 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