{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:19:11Z","timestamp":1791854351233,"version":"4.3.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%). On average, the patients had moderate ventilatory impairment (forced vital capacity: 51%predicted), sleep apnoea (apnoea-hypopnea index: 25 events h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), sleep-related hypoventilation (transcutaneous carbon dioxide rise of 20 mmHg) and daytime hypercarbia (PCO\n                    <jats:sub>2<\/jats:sub>\n                    : 54 mmHg). Median durations of survival from HMV initiation were 1.0, 4.2, 9.9 and &gt;11.5 years for MND, PULM, NMCW and OHS, respectively. Independent predictors of death varied between primary indications for HMV; the predictors included (a) age in all groups except for MND (hazard ratios (HRs) 1.03\u20131.10); (b) cardiovascular disease (HR: 2.35, 95% confidence interval (CI): 1.08\u20135.10) in MND; (c) obesity (HR: 0.28, 95% CI: 0.13\u20130.62) and oxygen therapy (HR: 0.33, 95% CI: 0.14\u20130.79) in PULM; and (d) forced expiratory volume in 1 s (%predicted; HR: 0.93, 95% CI: 0.88\u20131.00) in OHS.\n                  <\/jats:p>","DOI":"10.1177\/1479972318755723","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T21:55:09Z","timestamp":1518040509000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Patterns of use, survival and prognostic factors in patients receiving home mechanical ventilation in Western Australia: A single centre historical cohort study"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-9854","authenticated-orcid":false,"given":"Geak Poh","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia"},{"name":"West Australian Sleep Disorders Research Institute, Nedlands, Western Australia"},{"name":"Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"McArdle","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia"},{"name":"West Australian Sleep Disorders Research Institute, Nedlands, Western Australia"},{"name":"University of Western Australia, Nedlands, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvinder Singh","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Curtin University, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia"},{"name":"West Australian Sleep Disorders Research Institute, Nedlands, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare Siobhan","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia"},{"name":"West Australian Sleep Disorders Research Institute, Nedlands, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhajan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia"},{"name":"West Australian Sleep Disorders Research Institute, Nedlands, Western Australia"},{"name":"University of Western Australia, Nedlands, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"bibr1-1479972318755723","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00038503"},{"key":"bibr2-1479972318755723","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12376"},{"key":"bibr3-1479972318755723","first-page":"Cd004427","volume":"2013","author":"Radunovic A","year":"2013","journal-title":"Cochrane Database Syst 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