{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:16:24Z","timestamp":1781842584546,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001505","name":"The Health Research Council of New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    Vitamin D supplementation prevents acute respiratory infections and, through modulating innate and adaptive immunity, could have a potential role in bronchiectasis management. The primary aims of this pilot study were to assess serum 25-hydroxyvitamin D (25(OH)D) levels in New Zealand adults with bronchiectasis, and their 25(OH)D levels after vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation. Adults with bronchiectasis received an initial 2.5 mg vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    oral loading dose and 0.625 mg vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    weekly for 24 weeks. The primary outcome was serum 25(OH)D levels before and after vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation. Secondary outcomes (time to first infective exacerbation, exacerbation frequency, spirometry, health-related quality of life measures, sputum bacteriology and cell counts and chronic rhinosinusitis) were also assessed. This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN 12612001222831). The initial, average 25(OH)D level was 71 nmol\/L (95% confidence interval (CI): [58, 84]), rising to 218 nmol\/L (95% CI: [199, 237]) at 12 weeks and 205 nmol\/L (95% CI: [186, 224]) at 24 weeks. The initial serum cathelicidin level was 25 nmol\/L (95% CI: [17, 33]), rising to 102 nmol\/L (95% CI: [48, 156]) at 12 weeks and 151 nmol\/L (95% CI: [97, 205]) at 24 weeks. Over the 24-week study period, we observed statistically significant changes of 1.11 (95% CI: [0.08, 2.14]) in the Leicester Cough Questionnaire and \u22121.97 (95% CI: [\u22123.71, \u22120.23]) in the Dartmouth COOP charts score. No significant adverse effects were recorded. Many New Zealand adults with bronchiectasis have adequate 25(OH)D levels. Weekly vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation significantly improved 25(OH)D levels.\n                  <\/jats:p>","DOI":"10.1177\/1479972318761646","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:43:06Z","timestamp":1519864986000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D\n                    <sub>3<\/sub>\n                    supplementation in adults with bronchiectasis: A pilot study"],"prefix":"10.1177","volume":"15","author":[{"given":"Jim","family":"Bartley","sequence":"first","affiliation":[{"name":"Department of Surgery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-7654","authenticated-orcid":false,"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Scragg","sequence":"additional","affiliation":[{"name":"School of Population Health, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vandal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand"},{"name":"Ko Awatea, Counties Manukau District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Sisk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Milne","sequence":"additional","affiliation":[{"name":"Department of Radiology, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Jeon","sequence":"additional","affiliation":[{"name":"Middlemore Clinical Trials Unit, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Cursons","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, University of Waikato, Hamilton, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conroy","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Middlemore Hospital, Auckland, New 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