{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:52:59Z","timestamp":1777531979745,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373517"],"award-info":[{"award-number":["81373517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>\n                    Non-cystic fibrosis (non-CF) bronchiectasis is a condition characterized by an airway inflammatory response to bacterial pathogens. Frequent exacerbations have a major influence on the quality of life. Macrolide antibiotics have not only antibacterial but also immune-regulation effects. It is proved that macrolides have a benefit in preventing exacerbations. However, it is still uncertain whether azithromycin or erythromycin is more effective and safe. The purpose of this study was to answer the following question: Which kind of macrolide antibiotic is more effective and safe in preventing non-CF bronchiectasis exacerbation? We conducted a systematic review to identify randomized clinical trials published up to May 2017 that reported on macrolides for non-CF bronchiectasis and an adjusted indirect treatment comparison (AITC) between macrolides to evaluate their efficacy and safety. The direct comparison meta-analysis found that macrolides decreased the rate of exacerbation of non-CF bronchiectasis (risk ratio (RR) = 0.45; 95% confidence interval (CI) 0.36\u20130.55) with heterogeneity ( I\n                    <jats:sup>2<\/jats:sup>\n                    = 63.7%, p = 0.064). The AITC showed that azithromycin had a significantly lower bronchiectasis exacerbation rate than erythromycin (RR = 0.35; 95% CI: 0.403\u20130.947). Azithromycin increased the risk of diarrhea and abnormal pain. This meta-analysis suggested that long-term treatment with macrolides significantly reduced the incidence of non-CF bronchiectasis exacerbation. Moreover, azithromycin is more efficient than roxithromycin and erythromycin in preventing exacerbation.\n                  <\/jats:p>","DOI":"10.1177\/1479972318790269","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T02:30:51Z","timestamp":1534127451000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Azithromycin or erythromycin? Macrolides for non-cystic fibrosis bronchiectasis in adults: A systematic review and adjusted indirect treatment comparison"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-3312","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihui","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liancheng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Guiyang University of Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"bibr1-1479972318790269","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0411CI"},{"key":"bibr2-1479972318790269","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"issue":"5","key":"bibr3-1479972318790269","first-page":"Cd008351","author":"Lee AL","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr4-1479972318790269","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937"},{"key":"bibr5-1479972318790269","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39384.657118.80"},{"key":"bibr6-1479972318790269","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2209"},{"issue":"4","key":"bibr7-1479972318790269","first-page":"147","volume":"73","author":"Altenburg J","year":"2015","journal-title":"Neth J 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