{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:16:13Z","timestamp":1785525373631,"version":"3.56.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A \u2265 8 or\/and HADS-D \u2265 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Anchor- and distribution-based methods were used to estimate the MCID. HADS-A and HADS-D improved in response to PR in both patients with bronchiectasis and those with COPD (median (25th, 75th centile)\/mean (95% confidence interval) change: HADS-A change: bronchiectasis \u22122 (\u22125, 0), COPD \u22122 (\u22124, 0); p = 0.43 and HADS-D change: bronchiectasis \u22122 (\u22122 to \u22121), COPD \u22122 (\u22123 to \u22122); p = 0.16). Using 26 estimates, the MCID for HADS-A and HADS-D was \u22122 points. HADS-A and HADS-D are responsive to PR in patients with bronchiectasis and symptoms of mood disorder, with an MCID estimate of \u22122 points.<\/jats:p>","DOI":"10.1177\/1479973120933292","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:59:45Z","timestamp":1592362785000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale"],"prefix":"10.1177","volume":"17","author":[{"given":"Stephanie C","family":"Wynne","sequence":"first","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhani","family":"Patel","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E","family":"Barker","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Jones","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Walsh","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha SC","family":"Kon","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"The Hillingdon Hospitals NHS Foundation Trust, Uxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Cairn","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Loebinger","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wilson","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D-C","family":"Man","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-599X","authenticated-orcid":false,"given":"Claire M","family":"Nolan","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK"},{"name":"Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, 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