{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:55:18Z","timestamp":1777532118135,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Air stacking (AS) and mechanical insufflation\u2013exsufflation (MI-E) aim to increase cough efficacy by augmenting inspiratory lung volumes in patients with neuromuscular diseases (NMDs). We studied the short-term effect of AS and MI-E on lung function. We prospectively included NMD patients familiar with daily AS or MI-E use. Studied outcomes were forced vital capacity (FVC), forced expiratory volume in one second (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ), and peak expiratory flow (PEF) prior to, immediately after, and up to 2\u00a0h after treatment. Paired sample T-test and Wilcoxon signed-rank test was used. Sixty-seven patients participated. We observed increased FVC and FEV\n                    <jats:sub>1<\/jats:sub>\n                    immediately after AS with a mean difference of respectively 0.090\u00a0L (95% CI 0.045; 0.135, p &lt; .001) and 0.073\u00a0L (95% CI 0.017; 0.128, p = .012). Increased FVC immediately after MI-E (mean difference 0.059\u00a0L (95% CI 0.010; 0.109, p = .021) persisted 1\u00a0hour (mean difference 0.079\u00a0L (95% CI 0.034; 0.125, p = .003). The effect of treatment was more pronounced in patients diagnosed with Spinal Muscular Atrophy, compared to patients with Duchenne muscular dystrophy. AS and MI-E improved FVC immediately after treatment, which persisted 1\u00a0h after MI-E. There is insufficient evidence that short-lasting increases in FVC would explain the possible beneficial effect of AS and MI-E.\n                  <\/jats:p>","DOI":"10.1177\/14799731221094619","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T14:20:31Z","timestamp":1650464431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Short-term effect of air stacking and mechanical insufflation\u2013exsufflation on lung function in patients with neuromuscular diseases"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-9989","authenticated-orcid":false,"given":"Esther S","family":"Veldhoen","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit and Center of Home Mechanical Ventilation, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Vercoelen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit and Center of Home Mechanical Ventilation, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra","family":"Ros","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura P","family":"Verweij-van den Oudenrijn","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit and Center of Home Mechanical Ventilation, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roelie M","family":"W\u00f6sten-van Asperen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik HJ","family":"Hulzebos","sequence":"additional","affiliation":[{"name":"Child Development and Exercise Center, Wilhelmina Children\u2019s Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Bartels","sequence":"additional","affiliation":[{"name":"Child Development and Exercise Center, Wilhelmina Children\u2019s Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Gaytant","sequence":"additional","affiliation":[{"name":"Center of Home Mechanical Ventilation, Department of Pulmonology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kors","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children\u2019s Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Ludo van der Pol","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The 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