{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:43:30Z","timestamp":1791179010809,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Bronchiectasis is a heterogeneous disease with distinct phenotypes. The post-tuberculosis (post-TB) bronchiectasis phenotype is prevalent in many countries but is under-studied. Our aim was to identify distinct phenotypic characteristics of post-TB bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited adults admitted between Jan 2010-Oct 2017 at Changi General Hospital, Singapore for bronchiectasis exacerbation. We collected demographics, symptoms, lung function, microbiology and FACED scores. Participants were followed-up until the next hospitalized exacerbation or end of study, whichever was sooner. Participants diagnosed by their attending respiratory specialist to have post-TB bronchiectasis were compared to those with bronchiectasis from other aetiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      148 participants were included with mean\u00b1standard deviation age 63 \u00b1 9 years; 46 (31.1%) had post-TB bronchiectasis and 102 (68.9%) other aetiologies. Compared to other aetiologies, participants with post-TB bronchiectasis had significantly lower body mass index (BMI), more frequent presentation with haemoptysis, lower forced expiratory volume in one second (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), more frequent isolation of nontuberculous mycobacteria (NTM), and higher FACED scores indicating greater disease severity. Over a median follow-up of 21 months, post-TB bronchiectasis was associated with shorter time to next hospitalized exacerbation (49 vs 76 months, Log-Rank p = .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-TB bronchiectasis is a distinct entity with higher rates of haemoptysis and NTM isolation, more frequent exacerbations, and greater disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14799731221098714","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T15:17:12Z","timestamp":1650986232000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterisation of the post-tuberculous phenotype of bronchiectasis: A real-world observational study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-2137","authenticated-orcid":false,"given":"Isaac","family":"Fong","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teck Boon","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore"},{"name":"Respiratory Medicine, Raffles Specialist Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Yii","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"bibr1-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0042-3"},{"key":"bibr2-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02392-2018"},{"key":"bibr3-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201711-2202OC"},{"key":"bibr4-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01899-2015"},{"key":"bibr5-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02444-2017"},{"key":"bibr6-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31767-7"},{"key":"bibr7-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30053-5"},{"key":"bibr8-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0638-0"},{"key":"bibr9-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30327-4"},{"key":"bibr10-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12574"},{"key":"bibr11-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-1080-7"},{"key":"bibr12-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2002.00367.x"},{"key":"bibr13-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00334-2021"},{"key":"bibr14-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-000745"},{"key":"bibr15-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1159\/000512531"},{"key":"bibr16-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212463"},{"key":"bibr17-14799731221098714","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"bibr18-14799731221098714","volume-title":"Definitions 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