{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:55:52Z","timestamp":1777532152331,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Objectives: Ground-based walking is a simple training modality which would suit pulmonary rehabilitation (PR) settings with limited access to specialist equipment. Patients with COPD are, however, unable to walk uninterruptedly at a relatively fast walking pace to optimise training benefits. We compared an intermittent (IntSW) to a continuous (CSW) shuttle walking protocol.<\/jats:p>\n                  <jats:p>\n                    Methods: In 14 COPD patients (mean \u00b1 SD. FEV\n                    <jats:sub>1<\/jats:sub>\n                    : 45 \u00b1 21% predicted) we measured walking distance, cardiac output (CO), arterial oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ), and symptoms during (a) an IntSW protocol, consisting of 1-min walking alternating with 1-min rest, and (b) a CSW protocol, both sustained at 85% of predicted VO\n                    <jats:sub>2<\/jats:sub>\n                    peak to the limit of tolerance (Tlim).\n                  <\/jats:p>\n                  <jats:p>\n                    Results: Median (IQR) distance was greater ( p = 0.001) during the IntSW protocol (735 (375\u20131107) m) than the CSW protocol (190 (117\u2013360) m). At iso-distance (distance at Tlim during CSW) the IntSW compared to the CSW protocol was associated with lower CO (8.6 \u00b1 2.6 vs 10.3 \u00b1 3.7\u00a0L\/min; p = 0.013), greater SpO\n                    <jats:sub>2<\/jats:sub>\n                    (92 \u00b1 6% versus 90 \u00b1 7%; p = 0.002), and lower symptoms of dyspnoea (2.8 \u00b1 1.3 vs 4.9 \u00b1 1.4; p = 0.001) and leg discomfort (2.3 \u00b1 1.7 vs 4.2 \u00b1 2.2; p = 0.001). At Tlim symptoms of dyspnoea and leg discomfort did not differ between the IntSW (4.4 \u00b1 1.9 and 3.6 \u00b1 2.1, respectively) and the CSW protocol.\n                  <\/jats:p>\n                  <jats:p>Conclusions: The IntSW protocol may provide important clinical benefits during exercise training in the PR settings because it allows greater work outputs compared to the CSW.<\/jats:p>","DOI":"10.1177\/14799731221142023","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T12:36:31Z","timestamp":1671712591000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Greater exercise tolerance in COPD during acute intermittent compared to continuous shuttle walking protocols: A proof-of-concept study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-4363","authenticated-orcid":false,"given":"Charikleia","family":"Alexiou","sequence":"first","affiliation":[{"name":"Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Chambers","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Services, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Megaritis","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynsey","family":"Wakenshaw","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Services, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Echevarria","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Vogiatzis","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"bibr1-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"bibr2-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-1966ST"},{"key":"bibr3-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215281"},{"key":"bibr4-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-020-00210-y"},{"key":"bibr5-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31824660bd"},{"key":"bibr6-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.106"},{"key":"bibr7-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/S1836-9553(10)70040-0"},{"key":"bibr8-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.10.008"},{"key":"bibr9-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2016.02.014"},{"key":"bibr10-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000074"},{"key":"bibr11-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.08.011"},{"key":"bibr12-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00078014"},{"key":"bibr13-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.04.024"},{"key":"bibr14-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.03.007"},{"key":"bibr15-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00000513"},{"key":"bibr16-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.01.053"},{"key":"bibr17-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1113\/JP279531"},{"key":"bibr18-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.026617"},{"key":"bibr19-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.01152001"},{"key":"bibr20-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-020-00167-y"},{"key":"bibr21-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1177\/14799731211041506"},{"key":"bibr22-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.12.1019"},{"key":"bibr23-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.3.213"},{"key":"bibr24-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13002"},{"key":"bibr25-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000226"},{"key":"bibr26-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1007\/s004210100458"},{"key":"bibr27-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.090167"},{"key":"bibr28-14799731221142023","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"bibr29-14799731221142023","volume":"53","author":"Philips 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