{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:58:37Z","timestamp":1784098717409,"version":"3.55.0"},"reference-count":7,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Reduced diffusion capacity (DLCO) after COVID 19 pneumonia was reported in hospitalised patients after discharge. Here, we studied the restoration of DLCO over a 24\u00a0months period in COVID-19 pneumonia survivors ( n = 317), who were categorised into \u201cmoderate\u201d cases (no oxygen supply; no need for hospitalisation), \u201csevere\u201d cases (respiratory frequency &gt; 30\/min and\/or peripheral oxygen SpO2 &lt; 93%), and \u201ccritical\u201d cases (respiratory failure and admission into the intensive care unit). COVID-19 pneumonia survivors with a decreased DLCO (&lt;80%) at 3\u00a0months ( n = 133) were invited for 6- and 24-months follow-up. At 3\u00a0months, impairment of DLCO was more severe in critical case ( p &lt; .01). Over time, the subgroups showed a similar level of improvement; and, there was no difference in recovery over time between the subgroups. At 24\u00a0months, the DLCO did not differ between the subgroups, with a mean DLCO of 73% for all patients. At 24\u00a0months, 65% of patients still had a DLCO &lt; 80%, and in 40% of patients DLCO was &lt;70% of predicted. Regardless the initial disease severity, all COVID-19 survivors showed improvement in DLCO during follow-up; however, DLCO had not normalised in the majority of patients with a DLCO &lt;80% 3\u00a0months after hospital discharge.<\/jats:p>","DOI":"10.1177\/14799731231222284","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T04:56:47Z","timestamp":1707454607000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Two-year diffusion capacity trajectory in COVID-19 pneumonia survivors"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-6700","authenticated-orcid":false,"given":"Marlise P","family":"de Roos","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M","family":"Heijnen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nynke G","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nini H","family":"Jonkman","sequence":"additional","affiliation":[{"name":"Department of Research and Epidemiology, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bresser","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"bibr1-14799731231222284","doi-asserted-by":"publisher","DOI":"10.1177\/14799731221114271"},{"key":"bibr2-14799731231222284","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00004-2022"},{"key":"bibr3-14799731231222284","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101668"},{"key":"bibr4-14799731231222284","unstructured":"WHO coronavirus (COVID-19) dashboard. Available at: https:\/\/covid19.who.int"},{"key":"bibr5-14799731231222284","volume-title":"Clinical management of severe acute respiratory infection (SARI) when COVID-19 356 disease is suspected Interim guidance","year":"2020"},{"key":"bibr6-14799731231222284","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"bibr7-14799731231222284","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00016-2016"}],"container-title":["Chronic Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14799731231222284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14799731231222284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14799731231222284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:47:55Z","timestamp":1777394875000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/14799731231222284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":7,"alternative-id":["10.1177\/14799731231222284"],"URL":"https:\/\/doi.org\/10.1177\/14799731231222284","relation":{},"ISSN":["1479-9731","1479-9731"],"issn-type":[{"value":"1479-9731","type":"print"},{"value":"1479-9731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"14799731231222284"}}