{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:09:07Z","timestamp":1792004947984,"version":"4.4.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The paradigm of bronchiectasis is shifting away from its exclusive characterization as a neutrophilic condition. Patients with bronchiectasis and high eosinophil levels have been found to have a specific phenotype, but the clinical effect of eosinopenia remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective, single-center, observational study was conducted at a tertiary medical center. Adult patients under follow-up for bronchiectasis from January 2007 to August 2020 were categorized by blood eosinophil count (BEC) as follows: eosinopenia (&lt;100\u00a0cells\/\u00b5L), normal (100-299\u00a0cells\/\u00b5L), and eosinophilia (\u2265300\u00a0cells\/\u00b5L). Data on the first hospitalization due to exacerbation and the community exacerbation rate in the first year of follow-up were analyzed. Mortality rates were assessed up to the end of follow-up on September 1, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort included 724 patients (100%), 61% female ( n = 442), of mean age 61 \u00b1 16\u00a0years. The median follow-up period was 7.5 years (IQR: 5.1\u201310.8). Eosinopenia was found in 14.7% ( n = 107), normal BEC in 56.6% ( n = 417), and eosinophilia in 28.7% ( n = 200). Patients with eosinopenia had a higher hazard ratio for first hospitalization than the normal-count group (1.71, 95% CI 1.11\u20132.64, p = .01) and the highest mean exacerbation rate ( p = .04). On multivariate analysis, eosinopenia was significantly associated with higher mortality (HR 2.15, 95% CI 1.42\u20133.24, p &lt; .001) after adjusting for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eosinopenia in bronchiectasis emerged as a potential biomarker for adverse outcomes. Further study of its role in disease behavior may provide insights for the development of therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14799731241296847","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:03:19Z","timestamp":1735887799000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Eosinopenia in bronchiectasis: A novel biomarker for morbidity and mortality"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-1057","authenticated-orcid":false,"given":"Shimon","family":"Izhakian","sequence":"first","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravid","family":"Yehezkely","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"The Adelson School of Medicine, Ariel University, Ariel, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Frajman","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Mekiten","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Hadar","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avigail","family":"Rockland","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liel","family":"Malka","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-3876","authenticated-orcid":false,"given":"Lev","family":"Freidkin","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"bibr1-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212463"},{"key":"bibr2-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.02.024"},{"key":"bibr3-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02023-8"},{"key":"bibr4-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1889OC"},{"key":"bibr5-14799731241296847","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168431"},{"key":"bibr6-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.04.029"},{"key":"bibr7-14799731241296847","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196417"},{"key":"bibr8-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00277-0"},{"key":"bibr9-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00051-2017"},{"key":"bibr10-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2018.026492"},{"key":"bibr11-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.09.005"},{"key":"bibr12-14799731241296847","doi-asserted-by":"publisher","DOI":"10.4102\/ajlm.v4i1.208"},{"key":"bibr13-14799731241296847","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S265275"},{"key":"bibr14-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8525-4"},{"key":"bibr15-14799731241296847","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202103"}],"container-title":["Chronic 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