{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:00:27Z","timestamp":1777532427001,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2511097, 82170046, 82470062, and 82300050"],"award-info":[{"award-number":["W2511097, 82170046, 82470062, and 82300050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n Background<\/jats:title>\n \n Although the postbronchodilator FEV\n 1<\/jats:sub>\n \/FVC is the gold standard for diagnosing COPD, it is not easily obtainable due to various reasons. This study aims to investigate whether FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n may serve as an easily accessible surrogate for FEV\n 1<\/jats:sub>\n \/FVC in detecting airway obstruction and COPD.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eligible articles were screened from PubMed, Web of Science and Scopus. The Quality Assessment of Diagnostic Accuracy Studies-2 was applied for quality assessment. The pooled sensitivity, specificity, and area under the curve (AUC) of the summary receiver operating curve were calculated to evaluate the diagnostic performance of FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n in detecting airway obstruction and COPD and to determine the optimal cutoff value. Sensitivity analyses, subgroup analyses and meta-regression were performed to explore the source of heterogeneity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n With 28 eligible articles and 65,744 subjects, the FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n ratio showed good diagnostic performance in detecting both airway obstruction (sensitivity: 0.87, specificity: 0.94, AUC 0.95) and COPD (sensitivity: 0.83, specificity: 0.88, AUC 0.91). Further analyses of the optimal cutoff value suggested that an FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n <0.72 was the best criterion for detecting airway obstruction (sensitivity: 0.84, specificity: 0.97, AUC 0.96), whereas an FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n <0.74 was the best criterion for detecting COPD (sensitivity: 0.87, specificity: 0.89, AUC 0.93). The results of subgroup analyses and meta-regression suggested that study design and geographical location may affect the heterogeneity of both sensitivity and specificity in detecting airway obstruction and COPD.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n may serve as an easily accessible alternative in detecting airway obstruction and COPD. However, application of FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n may also be constrained by availability and affordability of devices. Further studies are required to determine the best-suited population for FEV\n 1<\/jats:sub>\n \/FEV\n 6<\/jats:sub>\n application.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/14799731261431251","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:04:42Z","timestamp":1773324282000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of FEV\n 1<\/sub>\n \/FEV\n 6<\/sub>\n in detecting airway obstruction and chronic obstructive pulmonary disease: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"23","author":[{"given":"Dongru","family":"Du","sequence":"first","affiliation":[{"name":"West China Hospital, Sichuan University"},{"name":"West China Hospital, Sichuan University"},{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sike","family":"He","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-6559","authenticated-orcid":false,"given":"Jiangyue","family":"Qin","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"},{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Gao","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"},{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Li","sequence":"additional","affiliation":[{"name":"Sixth People\u2019s Hospital of Chengdu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenni","family":"Chen","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"},{"name":"West China Hospital, Sichuan University"},{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-1792","authenticated-orcid":false,"given":"Yongchun","family":"Shen","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"},{"name":"West China Hospital, Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00470-6"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00511-7"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30841-9"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202302-0289OC"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30103-6"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S287172"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61290-3"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.5692"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01519-2022"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02014-9"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1146"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0350-2020"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0723"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1232"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.10.034"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-9"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.70000"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14020576"},{"key":"e_1_3_7_23_2","doi-asserted-by":"crossref","unstructured":"Alotaibi NA-O Borg BM Abramson MA-O et al. 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