{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:03:17Z","timestamp":1779696197963,"version":"3.53.1"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100022752","name":"MSD Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022752","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merck & Co., Inc"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chron Respir Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aims to characterize the patient journey for refractory chronic cough (RCC) or unexplained chronic cough (UCC) before visiting the Isala Chronic Cough Clinic (ICCC) in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data from 152 patients with RCC or UCC was collected between January 2017 and September 2021from General Practitioner (GP) and hospital charts, the EQ-5D-5L questionnaire, and a patient survey about the care pathway and cough impact on everyday life, based on a single-centre, observational, retrospective study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age at first ICCC visit was 60.3 \u00b1 11.6 years; 66.4% of patients was female. More patients had RCC (80.9%) than UCC (19.1%). Mean cough duration before ICCC visit was 8.5 \u00b1 6.5 years. 41.4% of patients reported cough &gt;10 years. Common patient-reported problems were social embarrassment (58.0%), exhaustion (54.2%), and sleep disturbance (45.0%). Urinary incontinence was prevalent among women (48.9%). Prior to ICCC, 59.2% had consulted 2\u20134 specialists for their cough and 16.2% had seen more than 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the long time to diagnosis of RCC or UCC, and the negative effect on patients\u2019 physical and psychological health, and everyday activities. Increased awareness may shorten time for diagnosis, and novel therapies may help reduce this disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14799731261446951","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:55:59Z","timestamp":1779512159000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A retrospective study to understand the journey and health status of patients with unexplained or refractory chronic cough in the Netherlands"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-0482","authenticated-orcid":false,"given":"Jan Willem Karel","family":"van den Berg","sequence":"first","affiliation":[{"name":"Isala Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-5035","authenticated-orcid":false,"given":"Mireille","family":"Edens","sequence":"additional","affiliation":[{"name":"Isala Academy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-0699","authenticated-orcid":false,"given":"Anoe Radha","family":"Oedit Doeb\u00e9","sequence":"additional","affiliation":[{"name":"MSD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"van der Velden","sequence":"additional","affiliation":[{"name":"MSD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5291-2292","authenticated-orcid":false,"given":"Maxime Roosje","family":"Heezen","sequence":"additional","affiliation":[{"name":"MSD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00420-2021"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00806-2023"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00300-2019"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00218714"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00217813"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01136-2019"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1496"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.06.024"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2023-220592"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00232-2022"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02348-5"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.15.1657"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.339"},{"key":"e_1_3_8_15_2","volume-title":"Evidence profile: urinary incontinence","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. (2017). Integrated care for older people: guidelines on community-level interventions to manage declines in intrinsic capacity. Evidence profile: urinary incontinence. Available from. https:\/\/www.who.int\/ageing\/health-systems\/icope\/evidence-centre\/ICOPE-evidence-profile-urinary-incont.pdf. 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