{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:12:19Z","timestamp":1792001539121,"version":"4.4.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011946","name":"Abbott Diabetes Care","doi-asserted-by":"crossref","award":["No Grant Number"],"award-info":[{"award-number":["No Grant Number"]}],"id":[{"id":"10.13039\/100011946","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>FreeStyle Libre\u00ae systems are effective and convenient glucose flash monitoring (FM) devices. This cost analysis compared FM versus self-monitoring of blood glucose (SMBG) in poorly controlled (glycated hemoglobin [HbA1c] &gt;8%) patients with type 2 diabetes (T2D) on basal insulin in Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A model was used to compare the costs of FM and SMBG in a 1000-patient cohort. All model inputs were sourced from scientific literature and validated by a multidisciplinary experts\u2019 group. Unitary costs were included in euros (2025), including value-added tax (VAT). The daily use of 2.5 strips (\u20ac0.57\/strip) and 2.5 lancets (\u20ac0.14\/lancet) was considered for SMBG according to Spanish recommendations. The events\/person-year was 2.5 for severe hypoglycemic events (SHEs) (\u20ac1403.03\/event), 17.02 for non-SHEs (NSHEs) (\u20ac3.92\/event), and 0.0025 for diabetic ketoacidosis (DKA) (\u20ac2523.93\/event). FM reduced the use of strips\/lancets (\u221283.0%; sensor: \u20ac3.00\/day) and acute events (NSHEs\/SHEs: \u221258.0%; DKA: \u221268.0%). Sensitivity analyses were conducted to test robustness. Two additional scenarios were studied, including chronic diabetic complications (absolute reduction in HbA1c with FM: \u22121.1%) and absenteeism-related costs (reduction in absenteeism with FM: \u221258.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The annual cost per patient was \u20ac3299.99 with SMBG and \u20ac2320.20 with FM. In 1000 patients, FM averted 2162 NSHEs (FM vs. SMBG: \u2212\u20ac66,672), 1450 SHEs (FM vs. SMBG: \u2212\u20ac2,579,224), and 1.5 DKA (FM vs. SMBG: \u2212\u20ac6310), producing total cost savings of \u20ac979.706 compared with SMBG. All sensitivity analyses confirmed cost savings of FM versus SMBG, even when strips\/lancets were free (\u2212\u20ac442,117) or assuming a lower SHE frequency (1.4 events\/patient-year; \u2212\u20ac321,488). In 1000 patients, when considering chronic diabetic complications (SMBG: \u20ac3,745,869; FM: \u20ac2,886,785) and absenteeism (SMBG: \u20ac237,990; FM: \u20ac99,004), the annual cost savings of FM versus SMBG rose to \u20ac1,997,777.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>FreeStyle Libre could reduce acute events, chronic diabetic complications, and work absenteeism in poorly controlled patients with T2D on basal insulin, generating cost savings for the Spanish health system and society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251363576","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:34:46Z","timestamp":1759250086000},"page":"55-67","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cost Analysis of the FreeStyle Libre Systems in People with Type 2 Diabetes Mellitus on Basal Insulin with Poor Glycemic Control: A Spanish Perspective"],"prefix":"10.1177","volume":"28","author":[{"given":"Francisco Javier","family":"Ampudia-Blasco","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain."},{"name":"Medicine Faculty, University of Valencia, Valencia, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"INCLIVA Biomedical Research Institute, Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-3049","authenticated-orcid":false,"given":"Alberto","family":"de la Cuadra-Grande","sequence":"additional","affiliation":[{"name":"Pharmacoeconomcis &amp; Outcomes Research Iberia (PORIB), Paseo Joaqu\u00edn Rodrigo 4 \u2013 Letter I, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-043X","authenticated-orcid":false,"given":"Virginia","family":"Bellido","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n de Endocrinolog\u00eda y Nutrici\u00f3n, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Sevilla, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Cebri\u00e1n-Cuenca","sequence":"additional","affiliation":[{"name":"Centro de Salud de Cartagena Casco, Murcia, Spain."},{"name":"Instituto Murciano de Investigaci\u00f3n Biom\u00e9dica (IMIB), Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Mezquita-Raya","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Universitario de Torrec\u00e1rdenas, Almer\u00eda, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Carretero-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Hospital Universitario de Badajoz, Badajoz, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio-Miguel","family":"Hern\u00e1ndez Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitario Virgen de la Arrixaca, Medicine School, University of Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-6152","authenticated-orcid":false,"given":"Itziar","family":"Oyag\u00fcez","sequence":"additional","affiliation":[{"name":"Pharmacoeconomcis &amp; Outcomes Research Iberia (PORIB), Paseo Joaqu\u00edn Rodrigo 4 \u2013 Letter I, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-0091","authenticated-orcid":false,"given":"Fernando","family":"G\u00f3mez-Peralta","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Hospital General de Segovia, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_3_3_4_2","volume-title":"Diabetes","author":"World Health Organization (WHO)","year":"2023","unstructured":"World Health Organization (WHO). 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