{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:28:37Z","timestamp":1789752517780,"version":"4.0.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>CamAPS FX is a customizable hybrid closed-loop app with a default target glucose of 105 mg\/dL. The personal glucose target is user-adjustable in 1 mg\/dL increments between 80 and 198 mg\/dL in 30-min segments over 24 h. We assessed the impact of different personal glucose targets on glycemic control during real-world use of CamAPS FX in different age-groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed data from real-world CamAPS FX users from 11 countries across all age-groups (1 to 90 years), who used the system between December 1, 2022 and November 30, 2023, and had a minimum of 8 weeks of closed-loop use. Every sensor glucose reading was matched to the user-specified glucose target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 8604 users (mean age 32 \u00b1 19 years, median days of data 89 [IQR 59, 119]) were included. Personal glucose targets were most frequently used by very young children (&gt;50%), followed by school-aged children (&gt;40%). All other age-groups used the default target 65%\u201368% of the time. Overall, personal glucose targets &gt;120 mg\/dL were associated with time in target range &lt;70%. Time &lt;70 mg\/dL remained &lt;4% across targets, apart from at the lowest (80\u201389 mg\/dL). Older adults achieved time in range \u226570% across all targets. Very young children and young adults were only able to achieve time in range &gt;70% with targets set below the default, which was associated with time &lt;70 mg\/dL of &gt;4% in very young children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Personal glucose targets are frequently used, with clinical impact differing depending on user-age. Adjusting glucose targets may help to achieve recommended glycemic targets and individual glycemic goals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251376010","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T04:30:46Z","timestamp":1758342646000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Real-World Clinical Impact of Using Personal Glucose Targets in a Hybrid Closed-Loop System Differs According to Age"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-0979","authenticated-orcid":false,"given":"Julia","family":"Ware","sequence":"first","affiliation":[{"name":"Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom."},{"name":"Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bergford","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-7200","authenticated-orcid":false,"given":"Peter","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Sibayan","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata E.","family":"Wilinska","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom."},{"name":"Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ruan","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Hovorka","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom."},{"name":"Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0504"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00005-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907863"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205225"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-1550"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0442"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0578"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0433"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221145184"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0112"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1667"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16227"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111673"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2210834"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231185348"}],"container-title":["Diabetes Technology &amp; 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