{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:36:24Z","timestamp":1787312184872,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical option to mitigate the risk of anastomotic complications and preserve endogenous insulin secretion in patients undergoing pancreaticoduodenectomy. However, the utility of continuous glucose monitoring (CGM) in assessing islet graft performance remains poorly characterized. Thereby, the aim of this study was to investigate the relationship between CGM-derived glycemic metrics and islet function following TPIAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Ten patients with pancreatic neoplasms (male\/female 5\/5, median age 60 [IQR 55\u201368] years) underwent TPIAT between September 2023 and March 2025 at the Verona University Hospital, receiving a median islet dose of 1912 IEQ\/kg [IQR 1724\u20133074]. CGM data were collected at 3 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10), 6 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8), and 12 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7) months post-transplantation. Islet metabolic function was assessed using Igls criteria and BETA-2 score. CGM metrics were compared across Igls-defined graft function categories and correlated with BETA-2 scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 25 total assessments, islet function was classified as optimal (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10), good (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6), marginal (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8), or failure (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1). Median BETA-2 score decreased significantly across these groups (19.4, 13.6, 5.3, 1.4, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Optimal function was associated with superior glycemic control (time in range, TIR: 97.0%; time in tight range, TITR: 86.5%; time above range, TAR: 1.5%) and lower glycemic variability (coefficient of variation, CV: 20.5%; glycemia risk index, GRI: 44.0), compared with good and marginal groups (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). These same CGM metrics were significantly correlated with both Igls classification and BETA-2 score (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CGM parameters reflect islet graft performance following TPIAT and are strongly correlated with established markers of \u03b2-cell function. Metrics such as TIR, TITR, TAR, CV, and GRI may serve as practical and sensitive tools for post-transplant metabolic surveillance in endocrine clinical practice.<\/jats:p>\n                    <jats:p>\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" orientation=\"portrait\" position=\"float\" xlink:href=\"10.1177_15209156251380857-fig3.tif\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251380857","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T01:31:42Z","timestamp":1759195902000},"page":"348-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Glucose Monitoring and Long-Term Assessment of Islet Function in Autologous Islet Transplantation after Total Pancreatectomy for Neoplasm: Preliminary Insights from a Prospective Study"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-4998","authenticated-orcid":false,"given":"Alessandro","family":"Csermely","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Tuveri","sequence":"additional","affiliation":[{"name":"General and Pancreatic Surgery Department, Pancreas Institute, University Hospital of Verona, Verona, Italy."},{"name":"Department of General and Oncological Surgery, G. Brotzu Hospital, Cagliari, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Lionetto","sequence":"additional","affiliation":[{"name":"General and Pancreatic Surgery Department, Pancreas Institute, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fontana","sequence":"additional","affiliation":[{"name":"General and Pancreatic Surgery Department, Pancreas Institute, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Mansueto","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Diagnostics and Public Health, Policlinico GB Rossi, University of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Turazzini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"Sheiban","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Colombini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Nocilla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Marruganti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Melzi","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Nano","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University Hospital of Verona, Verona, 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