{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:30:16Z","timestamp":1793219416355,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medtronic External Research Program","award":["ERP-2022-13339"],"award-info":[{"award-number":["ERP-2022-13339"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postprandial glucose control remains a challenge in people with type 1 diabetes (T1D), even when using advanced hybrid closed-loop systems (AHCL) such as the MiniMed\u2122 780G (MM780G) system. Missed mealtime boluses are common and can significantly impair glycemic outcomes. This study aimed to evaluate a corrective postprandial bolus strategy for missed meal boluses using the MM780G system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective, open-label, real-world study, 32 adults with T1D using the MM780G system completed three meal scenarios with standardized meals (\u223c60 g carbohydrates). The strategies were: (E1) premeal bolus (control), (E2) no bolus (relying on system automation), and (E3) delayed bolus (bolus covering 50% of carbohydrate content, 60 min postmeal). Each participant completed all strategies under remote supervision. Primary outcome was 4-h postprandial time in range (TIR, 70\u2013180 mg\/dL); secondary outcomes included time in tight range (TITR, 70\u2013140 mg\/dL), time above\/below range, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Premeal bolus (E1) achieved the highest TIR (85.5% \u00b1 18.8%), significantly outperforming both E2 (52.3% \u00b1 25.3%) and E3 (63.5% \u00b1 24.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). E3 also showed significant improvement over E2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). TITR followed a similar pattern. Time between 54 and 70 mg\/dL was slightly higher for E1 but remained within consensus goals. No significant differences in hypoglycemia (&lt;54 mg\/dL) were observed across strategies. Delayed bolus (E3) lowered time above 250 mg\/dL compared with E2. No severe hypoglycemia or ketoacidosis occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Premeal bolusing yields optimal postprandial glycemic control with the MM780G. However, when a meal bolus is missed, administering a corrective bolus of 50% carbohydrate content 1 h postmeal significantly improves TIR and TITR without increasing hypoglycemia risk. If correction is not performed, the MM780G system can provide a reasonable partial compensation via autobasal and auto-correction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251395010","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T04:14:51Z","timestamp":1763352891000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mitigation Strategies for a Missed Meal Bolus in People with Type 1 Diabetes Using the Minimed\n                    <b>\u2122<\/b>\n                    780G System"],"prefix":"10.1177","volume":"28","author":[{"given":"Bruno A.","family":"Grassi","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Onetto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Mora","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Tapia","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Passi","sequence":"additional","affiliation":[{"name":"Escuela de Salud P\u00fablica, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Jofr\u00e9","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Castro","sequence":"additional","affiliation":[{"name":"Medtronic, Diabetes Latin America, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Medtronic Diabetes, Northridge, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vigersky","sequence":"additional","affiliation":[{"name":"Medtronic Diabetes, Northridge, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Cohen","sequence":"additional","affiliation":[{"name":"Medtronic International Trading Sarl, Tolochenaz, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05568-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab688"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06171-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15463"},{"issue":"2","key":"e_1_3_3_7_2","first-page":"98","article-title":"Control of post-prandial hyperglycemia\u2013an essential part of good diabetes treatment and prevention of cardiovascular complications","volume":"12","author":"Hanefeld M","year":"2002","unstructured":"Hanefeld M, , Temelkova-Kurktschiev T. 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