{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:13:44Z","timestamp":1787019224040,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize simplified meal bolus strategies in adults with insulin-treated type 2 diabetes using automated insulin delivery (AID).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>In the 2IQP study, a 13-week randomized, controlled trial comparing Control-IQ+ AID to continuation of pre-study insulin regimen with continuous glucose monitoring, 201 participants in the AID arm were classified by meal bolus strategy. Glycemic outcomes were compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      68 participants\u2019 meal bolus strategies (33.8%) were classified as Carbohydrate Counting, 79 (39.3%) were classified as Preset Carbohydrate Amounts, 27 (13.4%) were classified as Fixed Insulin Doses, and 27 (13.4%) as Other Methods. All bolus strategies were associated with similar, significant improvements in HbA1c from baseline: \u22120.9% for Carbohydrate Counting (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), \u22121.1% for Preset Carbohydrate Amounts (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), \u22120.8% for Fixed Insulin Doses (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and \u22120.9% for Other Methods (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003). Hypoglycemia rates were low at baseline and remained low for all bolus strategies. As participants gained experience with the Control-IQ+ AID system, more participants opted to use a simplified bolus strategy in the second half of the study compared with the first half (63% vs. 52%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Simplified bolus strategies worked well for adults with type 2 diabetes using Control-IQ+ in the 2IQP trial. All bolus strategies led to substantial HbA1c improvements, without safety concerns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251395035","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:49:25Z","timestamp":1763657365000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Simplified Meal Bolus Strategies with Control-IQ+ Automated Insulin Delivery Are Safe and Effective in Adults with Type 2 Diabetes"],"prefix":"10.1177","volume":"28","author":[{"given":"Carol J.","family":"Levy","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kanapka","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Center for Diabetes Technology, University of Virginia, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Marks","sequence":"additional","affiliation":[{"name":"Rainier Clinical Research Center, Renton, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Spaic","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, St. Joseph\u2019s Health Care, Lawson Health Research Institute, London, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin W.","family":"Steenkamp","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA."},{"name":"Boston Medical Center, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia S.","family":"Lu","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Lum","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy W.","family":"Beck","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Pinsker","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the 2IQP Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0164"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S13907"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S87935"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2415948"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X07304449"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-1125"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.111006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-2297"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1692"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/15209156251362700"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06319-w"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0558"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.8.1330"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.59348"},{"key":"e_1_3_2_16_2","unstructured":"Pasquel FJ Forlenza G. Omnipod\u00ae 5: Advancing Automated Insulin Delivery for All. 2024. Available from: https:\/\/events.diabetes.org\/p\/s\/omnipod-r-5-advancing-automated-insulin-delivery-for-all-presented-by-insulet-3115 [Last accessed: September8 2025]."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2024.0586"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15209156251395035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156251395035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156251395035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:45:10Z","timestamp":1777707910000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15209156251395035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1177\/15209156251395035"],"URL":"https:\/\/doi.org\/10.1177\/15209156251395035","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}