{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:05:42Z","timestamp":1792919142260,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the long-term effectiveness and safety of the AndroidAPS (AAPS) system in adults with type 1 diabetes (T1D) under real-world clinical conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, single-center study included 27 adults with T1D (mean age 39 \u00b1 9.6 years; 55.6% women; diabetes duration 21.5 \u00b1 11.3 years) who initiated AAPS and were followed for 12 months. Glycemic metrics were obtained from real-time continuous glucose monitoring (rtCGM) data. Primary outcomes were changes in time in range (TIR; 70\u2013180 mg\/dL) and HbA1c. Secondary outcomes included time in tight range (TITR; 70\u2013140 mg\/dL), time below range (TBR), coefficient of variation (CV), and the glycemic risk index (GRI). Safety outcomes included severe hypoglycemia and diabetic ketoacidosis (DKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      TIR increased from 67.8% at baseline to 84.1% at 6 months and 79.9% at 12 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). HbA1c decreased from 6.6% to 6.1% and 6.0%, respectively. TITR improved by 14.8% at 6 months and 10.6% at 12 months, while GRI decreased from 40.2 to 21.3. Over 88% of participants achieved TIR &gt; 70% and CV &lt; 36% at both follow-ups, and up to 74% achieved TITR &gt; 50% at 6 months, remaining at 63% at 12 months. No episodes of severe hypoglycemia or DKA were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>AAPS demonstrated sustained long-term effectiveness and safety in adults with T1D under real-world clinical practice conditions. Glycemic outcomes were comparable to those reported with commercially available closed-loop automated insulin delivery systems, supporting AAPS as a viable and effective advanced management option for T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251411937","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:54:17Z","timestamp":1769061257000},"page":"739-745","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Glycemic Outcomes with an Open-Source Automated Insulin Delivery System in Adults with Type 1 Diabetes: A 1-Year Real-World Observational Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Sandra","family":"Amuedo","sequence":"first","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain."},{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla. Sevilla, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Antequera-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda y Nutrici\u00f3n, Complejo Asistencial Universitario de Le\u00f3n, Le\u00f3n, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharona","family":"Azriel","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario Infanta Sof\u00eda, Madrid, Spain."},{"name":"Departamento de Medicina, FIIB-HUIS-HUHEN, Universidad Europea de Madrid, Facultad de Medicina, Salud y Deportes. Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30167-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296816665635"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0375"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231164166"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231153882"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-078171"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-073263"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248965"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203913"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0484"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15289"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0535"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0412"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/db18-352-OR"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018820950146"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14793"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2024.0556"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13810"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221085273"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0416"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-1474"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2196\/14087"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13190"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14439"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2024.0561"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15766"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0310"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156251411937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15209156251411937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156251411937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:11:22Z","timestamp":1784268682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15209156251411937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1177\/15209156251411937"],"URL":"https:\/\/doi.org\/10.1177\/15209156251411937","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]}}}