{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:00Z","timestamp":1792000500876,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008985","name":"Diab\u00e8te Qu\u00e9bec","doi-asserted-by":"crossref","award":["2024-10140"],"award-info":[{"award-number":["2024-10140"]}],"id":[{"id":"10.13039\/100008985","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Continuous ketone sensors have the potential to reduce diabetic ketoacidosis in type 1 diabetes. We evaluated the accuracy of a novel ketone sensor and quantified physiological ketone metrics during ketogenic diets in type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>Adult participants on automated insulin delivery wore SiBio continuous ketone sensors and underwent two 6-day ketogenic diets, in random order. The two diets were very-low carbohydrate (&lt;50 g\/day) and intermittent 12-h fasting. Between the two diets, participants were admitted for a 6- to 8-h insulin suspension experiment to assess sensor accuracy. Ketone sensor readings were compared with capillary levels by FreeStyle Libre 2 meter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen participants completed the study (age 36.5 [17.0] years, HbA1c 7.0% [0.6], insulin dose 0.72 [0.26] units\/kg) and provided 870 sensor-meter paired data points. The mean absolute difference (MAD) for ketone values &lt;0.6 mmol\/L was 0.1 (0.1) mmol\/L and the relative MADs for ketone values \u22650.6 and \u22651.0 mmol\/L were 24.2% (17.1) and 19.6% (13.3), respectively. During the ketogenic diets (155 days), there were 81 ketosis events (3.7 events\/week) \u22650.6 mmol\/L of more than 15 min, with a median duration of 60 (30\u2013105) min\/event. All ketosis events except one were asymptomatic. Glucose levels, basal insulin delivery, and time of the day were not related to ketosis events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SiBio ketone sensor demonstrated preliminary accuracy and reveals that benign, transient ketosis are common in type 1 diabetes during very-low carbohydrate states. This has implications on the utility of continuous ketone sensors in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>Clinicaltrials.gov NCT06420518.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156251412812","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:11:04Z","timestamp":1768475464000},"page":"682-688","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient Benign Ketosis Is Common in Type 1 Diabetes During Very-Low Carbohydrate States: Novel Data from Continuous Ketone Sensor"],"prefix":"10.1177","volume":"28","author":[{"given":"Nicholas","family":"Sabelli","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada."},{"name":"The Research Institute of McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa-Rosina","family":"Pasqua","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada."},{"name":"The Research Institute of McGill University Health Centre, Montreal, Quebec, Canada."},{"name":"Division of Endocrinology, McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Perz","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorsa","family":"Majdpour","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tsoukas","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada."},{"name":"The Research Institute of McGill University Health Centre, Montreal, Quebec, Canada."},{"name":"Division of Endocrinology, McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Haidar","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada."},{"name":"The Research Institute of McGill University Health Centre, Montreal, Quebec, Canada."},{"name":"Division of Endocrinology, McGill University Health Centre, Montreal, Quebec, Canada."},{"name":"Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0780"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0384"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.2744"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003461"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0924"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.18581"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968211035411"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968211008185"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15921"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/15209156251362494"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2316"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0548"},{"issue":"815","key":"e_1_3_4_15_2","first-page":"381","article-title":"The effects of prolonged muscular exercise on the metabolism","volume":"119","author":"Courtice F","year":"1936","unstructured":"Courtice F, , Douglas CG. The effects of prolonged muscular exercise on the metabolism. 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