{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:10:13Z","timestamp":1792084213926,"version":"4.4.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009940","name":"Lotto New Zealand","doi-asserted-by":"crossref","award":["R-LHR-2023-215456"],"award-info":[{"award-number":["R-LHR-2023-215456"]}],"id":[{"id":"10.13039\/501100009940","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medtronic Diabetes"},{"name":"Lions Clubs New Zealand District 202F"},{"name":"Spinal Cord Society of New Zealand"},{"name":"Otago Southland Diabetes Research Trust"},{"name":"Lloyd Morgan Lions Clubs Charitable Trust"},{"name":"Bowen Family Foundation"},{"DOI":"10.13039\/501100003189","name":"Freemasons New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003189","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Otago, Wellington"},{"DOI":"10.13039\/501100019168","name":"Starship Foundation","doi-asserted-by":"crossref","award":["SF4374"],"award-info":[{"award-number":["SF4374"]}],"id":[{"id":"10.13039\/501100019168","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To assess longer term outcomes of automated insulin delivery (AID) in young people (7\u201325 years) with type 1 diabetes (T1D) and baseline glycated hemoglobin (HbA1c) \u2265 69 mmol\/mol (8.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This 52-week, multicenter trial followed 74 participants through an initial 13-week randomized controlled trial comparing AID (MiniMed\u2122 780G [MM780G]) with standard care (multiple daily injections or continuous subcutaneous insulin infusion) and a 39-week continuation phase where all participants used AID. Due to differing AID exposure times, pooled data are presented for 39 weeks, with 52-week data reflecting extended follow-up for the \u201cAID first\u201d group. Outcomes included HbA1c, continuous glucose monitoring metrics, safety, system performance, and psychosocial measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Baseline mean (\u00b1 standard deviation) HbA1c for all participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 74) was 92 \u00b1 20 mmol\/mol (10.5 \u00b1 1.9%). At 52 weeks, the mean HbA1c for the \u201cAID first\u201d group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 34) was 67 \u00b1 18 mmol\/mol (8.3 \u00b1 1.6%), consistent with the 39-week value for all participants (67 \u00b1 12 mmol\/mol [8.3 \u00b1 1.1%]). This followed an initial rapid decrease (mean change: \u221228 [95% confidence interval (CI): \u221233, \u221223] mmol\/mol or \u22122.5 [95% CI: \u22123.0, \u22122.1] percentage points at 13 weeks post-AID) and stabilized from 26 weeks in the whole sample. Baseline mean time in range (TIR; 3.9\u201310 mmol\/L) for all available participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 68) was 23.1 \u00b1 13.4%. Following substantial improvement and stabilization with AID use, the mean TIR for the \u201cAID first\u201d group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 32) was 63.1 \u00b1 13.7% at 52 weeks. Compared with the 52 weeks before the trial, the diabetic ketoacidosis rate decreased substantially (mean difference: \u221235.7 events per 100 participant-years), and no severe hypoglycemia occurred. Improved treatment satisfaction and reduced fear of hypoglycemia were reported at 52 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In young people with T1D and markedly elevated glycemia, longer term AID use with MM780G provided substantial, sustained improvements in glycemia without compromising safety. These findings support broader AID adoption in this high-risk population (Australian New Zealand Clinical Trials Registry number ACTRN12622001454763).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156261426883","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:27:49Z","timestamp":1773253669000},"page":"980-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Extended Use of Automated Insulin Delivery in Young People with Type 1 Diabetes and Elevated HbA1c: 52-Week Outcomes of the CO-PILOT Trial"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0001-9441","authenticated-orcid":false,"given":"Marcus C.","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Boucsein","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Dunedin, New Zealand."},{"name":"Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venus R.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian J.","family":"Haszard","sequence":"additional","affiliation":[{"name":"Starship Child Health, Te Whatu Ora Te Toka Tumai Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Starship Child Health, Te Whatu Ora Te Toka Tumai Auckland, Auckland, New Zealand."},{"name":"Liggins Institute and Department of Paediatrics, University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esko J.","family":"Wiltshire","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand."},{"name":"Te Whatu Ora Capital, Coast and Hutt Valley, Wellington, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Paul","sequence":"additional","affiliation":[{"name":"Te Huatakia Waiora School of Health, University of Waikato, Hamilton, New Zealand."},{"name":"Waikato Regional Diabetes Service, Te Whatu Ora 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